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首页> 外文期刊>Academic radiology >Proton MR Spectroscopy of Central Neurocytoma Using Short and Long Echo Time. New Proofs for the Existence of Glycine and Glutamate
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Proton MR Spectroscopy of Central Neurocytoma Using Short and Long Echo Time. New Proofs for the Existence of Glycine and Glutamate

机译：中枢神经细胞瘤的质子MR光谱使用短而长的回声时间。 甘氨酸和谷氨酸存在的新证据

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摘要

Rationale and Objectives: Central neurocytomas (CNCs) are rare benign tumors typically located in the lateral ventricle of the central nervous system. The authors report five patients with CNCs and review 16 previously published studies that included 52 patients with CNCs to explore the magnetic resonance spectroscopic features of CNCs. Materials and Methods: Five patients with CNCs were retrospectively reviewed. They were examined using point-resolved spectroscopic series with short and/or long echo times. The integrals of choline, creatine, and the 3.55-ppm peak were determined using Magnetic Resonance User Interface software, and the metabolite ratios relative to creatine were obtained. In two cases, T2 relaxation times of choline and the metabolite resonance at 3.55 ppm were calculated using data points acquired with different echo times and an exponential decay model. Results: Consistent with previously published studies, all five patients showed highly increased choline and reduced N-acetylaspartate and creatine. Four patients in the present study and 35 in published data demonstrated prominent peaks at 3.55 ppm, which were assigned to glycine because of its relaxation pattern and long T2 relaxation time. In addition, increased in vivo glutamate and glutamine was also confirmed in three patients examined with short echo times. Alanine and lactate peaks were observed in three and two patients, respectively. Conclusions: The present study shows that the 3.55-ppm peak characteristic of CNC should be assigned to glycine according to its T2 relaxation time. Besides increased glycine and choline, the presence of glutamate or glutamine, which appears on series with short echo times, may further confirm the diagnosis of CNC.
机译：理由和目标：中枢神经细胞瘤（CNC）是罕见的良性肿瘤，通常位于中枢神经系统的侧腔内。作者报告了5例CNCS患者，并审查了16次出版的研究，其中包括52名CNC患者探讨CNCS的磁共振光谱特征。材料和方法：回顾性审查了5例CNC患者。使用短和/或长期回声次数使用点分辨的光谱系列进行检查。使用磁共振用户界面软件确定胆碱，肌酸和3.55-ppm峰的积分，获得相对于肌酸的代谢物比率。在两种情况下，使用具有不同回声次的数据点和指数衰减模型来计算胆碱的T2溶解时间和3.55ppm的代谢物共振。结果：与先前发表的研究一致，所有五名患者均显示出高度增加的胆碱和降低的N-乙酰己二酸盐和肌酸。本研究中的四名患者和发表的数据35例展示了3.55ppm的突出峰，由于其弛豫图案和长T2弛豫时间而分配给甘氨酸。此外，在体内谷氨酸和谷氨酰胺中也被证实了三个患者在检查短期时间。在三个和两名患者中观察到丙氨酸和乳酸峰。结论：本研究表明，应根据其T2弛豫时间将CNC的3.55ppm峰特征分配给甘氨酸。除了增加的甘氨酸和胆碱，谷氨酸或谷氨酰胺的存在还可以进一步证实CNC的诊断。

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  • 来源
    《Academic radiology》 |2012年第7期|共6页
  • 作者

    LiuM.; YueQ.; IsobeT.; MatsumuraA.; LiJ.; YangZ.; QuanH.; XingH.; GongQ.;

  • 作者单位

    Huaxi MR Research Center Department of Radiology West China Hospital of Sichuan University No 37;

    Huaxi MR Research Center Department of Radiology West China Hospital of Sichuan University No 37;

    Department of Neurosurgery Institute of Clinical Medicine University of Tsukuba Tsukuba Science;

    Department of Neurosurgery Institute of Clinical Medicine University of Tsukuba Tsukuba Science;

    Department of Geriatrics West China Hospital of Sichuan University No 37 Guo Xue Xiang Chengdu;

    Laboratory of Medical Physics Physics and Technology School Wuhan University Wuhan China;

    Laboratory of Medical Physics Physics and Technology School Wuhan University Wuhan China;

    Huaxi MR Research Center Department of Radiology West China Hospital of Sichuan University No 37;

    Huaxi MR Research Center Department of Radiology West China Hospital of Sichuan University No 37;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 放射医学;
  • 关键词

    Central neurocytoma; Glutamate; Glutamine; Glycine; Magnetic resonance spectroscopy;

    机译：中枢神经细胞瘤;谷氨酸;谷氨酰胺;甘氨酸;磁共振光谱;

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