...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Academic radiology >Reduced Insular Glutamine and N-Acetylaspartate in Systemic Lupus Erythematosus: A Single-Voxel 1H-MR Spectroscopy Study
【24h】

Reduced Insular Glutamine and N-Acetylaspartate in Systemic Lupus Erythematosus: A Single-Voxel 1H-MR Spectroscopy Study

机译：系统性红斑狼疮中的岛状谷氨酰胺和N-乙酰乙酰天冬氨酸减少：单体素1H-MR光谱研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Rationale and Objectives: To investigate for differences in metabolic concentrations and ratios between patients with systemic lupus erythematosus (SLE) without (group SLE) and those with neurological symptoms (group NPSLE) compared to a healthy control (group HC) in three normal-appearing brain regions: the frontal white matter, right insula (RI), and occipital gray matter and whether changes in any of the metabolites or metabolic ratios are correlated to disease activity and other clinical parameters. Materials and Methods: Twenty patients with SLE (18 women and 2 men, age range 23.4-64.6 years, mean age 43.9 years), 23 NPSLE patients (23 women, age range 23.7-69.8 years, mean age 42.4 years), and 21 HC (19 women and 2 men, age range 21.0-65.7 years, mean age 43.4 years) were included. All subjects had conventional brain magnetic resonance imaging and 1H single-voxel spectroscopy, clinical assessment, and laboratory testing. Results: NPSLE patients had significantly reduced N-acetylaspartate (NAA)/creatine compared to HC (. P = .02) and SLE patients (. P = .01) in the RI. Lower glutamine/creatine levels were also detected in RI in both patient groups and in frontal white matter in NPSLE patients compared to HC (. P = .01, P = .02). NAA/Cr ratio in the RI was significantly negatively correlated with the Systemic Lupus Erythematosus Disease Activity Index (. r =-0.41; P =.008), and patients with active SLE symptoms also had a trend toward lower NAA/creatine ratios (1.02 vs 1.12; P =.07). Conclusions: The present data support previous findings of abnormal metabolic changes in normal-appearing regions in the brain of both SLE and NPSLE patients and raise the possibility that especially NAA, glutamine, and glutamate may be additional biomarkers for cerebral disease activity in SLE patients as these early metabolic changes occur in the brain of SLE patients before neurologic and imaging manifestations become apparent.
机译：原理和目的：在三个正常出现的情况下，与健康对照组（HC组）相比，研究无系统性红斑狼疮（SLE）的患者（SLE组）和有神经系统症状的患者（NPSLE组）的代谢浓度和比率的差异脑区：额叶白质，右岛（RI）和枕部灰质，以及任何代谢物或代谢率的变化是否与疾病活动和其他临床参数相关。材料和方法：20例SLE患者（18例女性和2例男性，年龄23.4-64.6岁，平均年龄43.9岁），23例NPSLE患者（23例女性，年龄23.7-69.8岁，平均年龄42.4岁）和21例HC（19名女性和2名男性，年龄范围21.0-65.7岁，平均年龄43.4岁）包括在内。所有受试者均进行常规脑磁共振成像和1H单体素光谱，临床评估和实验室测试。结果：与RI的HC（。P = .02）和SLE患者（。P = .01）相比，NPSLE患者的N-乙酰天门冬氨酸（NAA）/肌酸明显降低。与HC相比，在两个患者组的RI和NPSLE患者的额白质中也检测到较低的谷氨酰胺/肌酸水平（。P = .01，P = .02）。 RI中的NAA / Cr比值与系统性红斑狼疮疾病活动指数显着负相关（。r = -0.41; P = .008），具有活动性SLE症状的患者也有降低NAA /肌酸比值的趋势（1.02 vs 1.12; P = .07）。结论：目前的数据支持先前发现的SLE和NPSLE患者大脑正常出现区域中异常代谢变化的发现，并增加了尤其是NAA，谷氨酰胺和谷氨酸可能是SLE患者脑疾病活动的其他生物标志物的可能性。这些早期代谢变化发生在SLE患者的大脑中，直到神经和影像学表现变得明显。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号