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首页> 外文期刊>Academic Medicine: Journal of the Association of American Medical Colleges >Reengineering the national clinical and translational research enterprise: the strategic plan of the National Clinical and Translational Science Awards Consortium.
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Reengineering the national clinical and translational research enterprise: the strategic plan of the National Clinical and Translational Science Awards Consortium.

机译：改造国家临床和转化研究企业：国家临床和转化科学奖联盟的战略计划。

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Advances in human health require the efficient and rapid translation of scientific discoveries into effective clinical treatments; this process, in turn, depends on observational data gathered from patients, communities, and public health research that can be used to guide basic scientific investigation. Such bidirectional translational science, however, faces unprecedented challenges due to the rapid pace of scientific and technological development, as well as the difficulties of negotiating increasingly complex regulatory and commercial environments that overlap the research domain. Further, numerous barriers to translational science have emerged among the nation's academic research centers, including basic structural and cultural impediments to innovation and collaboration, shortages of trained investigators, and inadequate funding.To address these serious and systemic problems, in 2006 the National Institutes of Health created the Clinical and Translational Science Awards (CTSA) program, which aims to catalyze the transformation of biomedical research at a national level, speeding the discovery and development of therapies, fostering collaboration, engaging communities, and training succeeding generations of clinical and translational researchers. The authors report in detail on the planning process, begun in 2008, that was used to engage stakeholders and to identify, refine, and ultimately implement the CTSA program's overarching strategic goals. They also discuss the implications and likely impact of this strategic planning process as it is applied among the nation's academic health centers.
机译：人类健康的进步要求将科学发现迅速有效地转化为有效的临床治疗方法;反过来，此过程取决于从患者，社区和公共卫生研究收集的观察数据，这些数据可用于指导基础科学研究。然而，由于科学和技术发展的迅速步伐以及谈判与研究领域重叠的日益复杂的监管和商业环境的困难，这种双向翻译科学面临着前所未有的挑战。此外，在美国的学术研究中心中，转化科学遇到了许多障碍，包括创新和协作的基本结构和文化障碍，训练有素的研究人员短缺以及资金不足.2006年，为了解决这些严重和系统性的问题，美国国立科学研究院卫生组织创建了临床和转化科学奖（CTSA）计划，该计划旨在促进国家一级生物医学研究的转型，加速疗法的发现和开发，促进合作，吸引社区参与，并培训后代的临床和转化研究人员。作者详细报告了始于2008年的规划过程，该过程用于吸引利益相关者，并确定，完善和最终实施CTSA计划的总体战略目标。他们还讨论了该战略规划流程在全国学术卫生中心中应用的含义和可能的影响。

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