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首页> 外文期刊>Academic radiology >The Significance of Alteration2-[fluorine-18]fluoro-2-deoxy-d-glucose Uptake in the Liver and Skeletal Muscles of Patients with Hyperthyroidism
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The Significance of Alteration2-[fluorine-18]fluoro-2-deoxy-d-glucose Uptake in the Liver and Skeletal Muscles of Patients with Hyperthyroidism

机译：甲亢患者肝，骨骼肌中2- [氟-18]氟-2-脱氧-d-葡萄糖摄取变化的意义

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Rationale and Objectives: Hyperthyroidism leads to an enhanced demand for glucose. The hypothesis of the study is that 2-[fluorine-18]fluoro-2-deoxy-. d-glucose (FDG) positron emission tomography (PET) can demonstrate the alteration of systemic glucose metabolism in hyperthyroidism patients by measuring the FDG standard uptake value (SUV) in liver and skeletal muscle. Materials and Methods: Forty-eight active hyperthyroidism patients and 30 control participants were recruited for the study. The intensity of FDG uptake in the liver and thigh muscles was graded subjectively, comprising three groups: group I, higher FDG uptake in the liver; group II, equal FDG uptake in the liver and muscles; and group III, higher FDG uptake in the muscles. Ten subjects with FDG PET scans at hyperthyroid and euthyroid status were analyzed. Serum levels of thyroxine (T4) and triiodothyronine (T3) correlated to the SUVs of the liver and muscles. Results: Forty-one patients (41/48, 85.4%) showed symmetrically increased FDG uptake in the muscles (22 in group I, 9 in group II, and 17 in group III). Group I patients were significantly older than group II (P=.02) and group III (P=.001) patients. The correlation coefficient between the serum T3, T4, and SUV levels in the muscles was significant (r=0.47-0.77, P.01), particularly in liver and muscle FDG uptake between hyperthyroid and euthyroid states. In the 30 control subjects, there was normal physiological FDG uptake in the liver and muscles. Conclusion: In PET scans showing a pattern of decreased liver and increased skeletal muscle FDG uptake in hyperthyroidism patients, this change of FDG distribution is correspondence to the severity of hyperthyroidism status.
机译：理由和目标：甲状腺功能亢进症导致对葡萄糖的需求增加。该研究的假设是2- [氟-18]氟-2-脱氧-。 d-葡萄糖（FDG）正电子发射断层扫描（PET）可通过测量肝脏和骨骼肌的FDG标准摄取值（SUV）来证明甲状腺功能亢进症患者体内全身葡萄糖代谢的改变。材料和方法：招募了48名活动性甲状腺功能亢进患者和30名对照组参与者。对肝脏和大腿肌肉中FDG摄取的强度进行主观分级，分为三组：第一组，肝脏中FDG摄取较高;第二组为高摄取。第二组，肝脏和肌肉中FDG的摄取相等;第三组，肌肉中较高的FDG摄取量。分析了十名在甲状腺功能亢进和正常状态下进行FDG PET扫描的受试者。血清甲状腺素（T4）和三碘甲状腺素（T3）与肝脏和肌肉的SUV相关。结果：41例患者（41 / 48，85.4％）显示肌肉中FDG摄取呈对称增加（I组22例，II组9例，III组17例）。 I组患者明显高于II组（P = .02）和III组（P = .001）。肌肉中血清T3，T4和SUV水平之间的相关系数显着（r = 0.47-0.77，P <.01），尤其是在甲亢和正常甲状腺状态之间肝脏和肌肉摄取FDG时。在30名对照受试者中，肝脏和肌肉中的生理性FDG摄取正常。结论：在PET扫描显示甲亢患者肝功能下降和骨骼肌FDG摄取增加的模式中，FDG分布的这种变化与甲亢状态的严重性相对应。

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