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首页> 外文期刊>Academic radiology >MR Elastography in Renal Transplant Patients and Correlation with Renal Allograft Biopsy. A Feasibility Study
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MR Elastography in Renal Transplant Patients and Correlation with Renal Allograft Biopsy. A Feasibility Study

机译：肾移植患者的MR弹性成像及其与肾同种异体移植活检的相关性。可行性研究

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Rationale and Objectives: Magnetic resonance elastography (MRE) images the propagation of mechanical shear waves in tissue and uses that information to generate quantitative measures of tissue stiffness. Hepatic MRE has been successfully performed in thousands of patients, with good correlation between histologic grade of fibrosis and tissue stiffness. There has been no prior investigation of the utility of MRE for the assessment of kidney transplants. The aims of this study were to prospectively evaluate the feasibility of MRE in a small group of kidney transplant recipients and to correlate the measured magnetic resonance elastographic stiffness values with biopsy-proven histopathologic fibrosis. Materials and Methods: MRE of renal transplants was performed in 11 patients returning for protocol allograft biopsies. Calculated tissue stiffness values were compared to histologic degree of fibrosis in nine of the 11 patients. Results: The mean stiffness of two patients with moderate interstitial fibrosis was higher than the mean of six patients with mild interstitial fibrosis, but not significantly so (90 Hz, P = .12; 120 Hz, P = .17; 150 Hz, P = .26). The mean stiffness of the two patients with moderate interstitial fibrosis was slightly greater than the mean of one patient with no significant interstitial fibrosis at 90 Hz (P = .78) and slightly less at 120 and 150 Hz (P = .88 and P = .76). The mean stiffness of the six patients with mild interstitial fibrosis did not differ significantly from that of the one patient with no interstitial fibrosis (90 Hz, P = .35; 120 Hz, P = .22; 150 Hz, P = .16). Conclusions: Preliminary results demonstrate feasibility and support known multifactorial influences on renal stiffness.
机译：原理和目的：磁共振弹性成像（MRE）对组织中机械剪切波的传播进行成像，并使用该信息生成组织硬度的定量度量。肝MRE已成功地在成千上万的患者中进行，组织学纤维化程度与组织硬度之间具有良好的相关性。以前没有对MRE在评估肾脏移植中的用途进行调查。这项研究的目的是前瞻性评估在少数肾脏移植受者中进行MRE的可行性，并将磁共振弹性成像硬度值与经活检证实的组织病理学纤维化相关联。材料和方法：对11例接受协议同种异体活检的患者进行了肾移植的MRE。在11例患者中的9例中，将计算的组织硬度值与纤维化的组织学程度进行了比较。结果：两名中度间质纤维化患者的平均硬度高于六名轻度间质纤维化患者的平均硬度，但均无统计学意义（90 Hz，P = .12; 120 Hz，P = .17; 150 Hz，P = 0.26）。两名中度间质纤维化患者的平均刚度略大于一名在90 Hz时无明显间质纤维化的患者的平均刚度（P = .78），而在120和150 Hz时则略低（P = .88和P = .76）。 6名轻度间质纤维化患者的平均刚度与1名无间质纤维化患者的平均刚度没有显着差异（90 Hz，P = 0.35; 120 Hz，P = 0.22; 150 Hz，P = 0.16） 。结论：初步结果证明可行性和支持已知的多因素影响肾硬度。

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