...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Academic radiology >Screening for familial intracranial aneurysms: decision and cost-effectiveness analysis.
【24h】

Screening for familial intracranial aneurysms: decision and cost-effectiveness analysis.

机译：家族性颅内动脉瘤的筛查：决策和成本效益分析。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

RATIONALE AND OBJECTIVES: To evaluate the potential benefits, harms, and cost-effectiveness of screening for asymptomatic, unruptured intracranial aneurysms in family members of patients with aneurysmal subarachnoid hemorrhage (SAH). MATERIALS AND METHODS: Using a Markov model, we performed a decision and cost-effectiveness analysis comparing magnetic resonance (MR) angiography screening for asymptomatic, unruptured intracranial aneurysms to no screening in family members of patients with aneurysmal SAH. Treatment of unruptured intracranial aneurysms was determined according to patient age and aneurysm size and location. Cohort age was taken as 40 years. RESULTS: In family members with two or more affected first-degree relatives, screening compared with no screening had an incremental cost-effectiveness ratio (ICER) of Dollars 37,400 per quality-adjusted life-year (QALY). With screening, life expectancy increased from 39.44 years to 39.55 years. The ICER of screening was >Dollars 50,000 per QALY if age at screening was > or =50 years. In family members with one affected first-degree relative, screening compared with no screening had an ICER of Dollars 56,500 per QALY. CONCLUSIONS: The results suggest that MR angiography screening for asymptomatic, unruptured intracranial aneurysms in family members with two or more affected first-degree relatives is cost-effective. The benefit and cost-effectiveness are dependent on age at screening.
机译：理由和目标：评估筛查无症状，不破裂的颅内动脉瘤的家庭成员的动脉瘤性蛛网膜下腔出血（SAH）患者的潜在益处，危害和成本效益。材料与方法：使用马尔可夫模型，我们对无症状，未破裂颅内动脉瘤的磁共振（MR）血管造影筛查与无动脉瘤SAH患者家庭成员的筛查进行了比较，进行了决策和成本效益分析。根据患者年龄和动脉瘤的大小和位置确定颅内动脉瘤破裂的治疗方法。队列年龄为40岁。结果：在有两个或多个受影响的一级亲属的家庭成员中，筛查与不筛查相比，每质量调整生命年（QALY）的成本效益比（ICER）为37,400美元。通过筛查，预期寿命从39.44岁增加到39.55岁。如果筛查年龄大于或等于50岁，筛查的ICER为每QALY 50,000美元。在有一名受影响的一级亲属的家庭成员中，筛查与未筛查相比，每个QALY的ICER为56,500美元。结论：结果表明，MR血管造影筛查有两个或多个一级亲属的家庭成员无症状，不破裂的颅内动脉瘤是具有成本效益的。收益和成本效益取决于筛查的年龄。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号