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首页> 外文期刊>Acta biomaterialia >Biological evaluation of an apatite-mullite glass-ceramic produced via selective laser sintering.
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Biological evaluation of an apatite-mullite glass-ceramic produced via selective laser sintering.

机译：通过选择性激光烧结生产的磷灰石-莫来石玻璃陶瓷的生物学评估。

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The biological performance of a porous apatite-mullite glass-ceramic, manufactured via a selective laser sintering (SLS) method, was evaluated to determine its potential as a bone replacement material. Direct contact and extract assays were used to assess the cytotoxicity of the material. A pilot animal study, implanting the material into rabbit tibiae for 4 weeks, was also carried out to assess in vivo bioactivity. The material produced by SLS did not show any acute cytotoxic effects by either contact or extract methods. There was no evidence of an apatite layer forming on the surface of the material when soaked in SBF for 30 days, suggesting that the material was unlikely to exhibit bioactive behaviour in vivo. It is hypothesized that the material was unable to form an apatite layer in SBF due to the fact that this glass-ceramic was highly crystalline and the fluorapatite crystal phase was relatively stable in SBF, as were the two aluminosilicate crystal phases. There was thus no release of calcium and phosphorus and no formation of silanol groups to trigger apatite deposition from solution within the test time period. Following implantation in rabbit tibiae for 4 weeks, bone was seen to have grown into the porous structure of the laser-sintered parts, and appeared to be very close to, or directly contacting, the material surface. This result may reflect the local environment in vivo compared to that artificially found with the in vitro SBF test and, furthermore, confirms previous in vivo data on these glass-ceramics.
机译：对通过选择性激光烧结（SLS）方法制造的多孔磷灰石-莫来石玻璃陶瓷的生物学性能进行了评估，以确定其作为骨替代材料的潜力。直接接触和提取物测定法用于评估材料的细胞毒性。还进行了一项先导动物研究，将其植入兔胫骨4周，以评估其体内生物活性。通过接触或提取方法，SLS生产的材料均未显示任何急性细胞毒性作用。在SBF中浸泡30天后，没有证据表明在材料表面形成磷灰石层，这表明该材料不太可能在体内表现出生物活性。假设该材料不能在SBF中形成磷灰石层，这是因为该玻璃陶瓷是高度结晶的，而氟磷灰石晶体相在SBF中相对稳定，就像两个铝硅酸盐晶体相一样。因此，在测试时间内没有释放钙和磷，也没有形成硅烷醇基团来触发磷灰石从溶液中沉积。在兔胫骨中植入4周后，发现骨骼已长成激光烧结部件的多孔结构，并且看起来非常靠近或直接接触材料表面。与通过体外SBF测试人工发现的结果相比，该结果可能反映了体内的局部环境，并且进一步证实了这些玻璃陶瓷的先前体内数据。

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