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首页> 外文期刊>Acta biomaterialia >Mechanical and microstructural properties of polycaprolactone scaffolds with one-dimensional, two-dimensional, and three-dimensional orthogonally oriented porous architectures produced by selective laser sintering.
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Mechanical and microstructural properties of polycaprolactone scaffolds with one-dimensional, two-dimensional, and three-dimensional orthogonally oriented porous architectures produced by selective laser sintering.

机译：具有一维，二维和三维正交定向多孔结构的聚己内酯骨架的机械和微观结构特性，这些骨架通过选择性激光烧结生产。

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This article reports on the experimental determination and finite element modeling of tensile and compressive mechanical properties of solid polycaprolactone (PCL) and of porous PCL scaffolds with one-dimensional, two-dimensional and three-dimensional orthogonal, periodic porous architectures produced by selective laser sintering (SLS). PCL scaffolds were built using optimum processing parameters, ensuring scaffolds with nearly full density (>95%) in the designed solid regions and with excellent geometric and dimensional control (within 3-8% of design). The tensile strength of bulk PCL ranged from 10.5 to 16.1 MPa, its modulus ranged from 343.9 to 364.3 MPa, and the tensile yield strength ranged from 8.2 to 10.1 MPa. These values are consistent with reported literature values for PCL processed through various manufacturing methods. Across porosity ranged from 56.87% to 83.3%, the tensile strength ranged from 4.5 to 1.1 MPa, the tensile modulus ranged from 140.5 to 35.5 MPa, and the yield strength ranged from 3.2 to 0.76 MPa. The compressive strength of bulk PCL was 38.7 MPa, the compressive modulus ranged from 297.8 to 317.1 MPa, and the compressive yield strength ranged from 10.3 to 12.5 MPa. Across porosity ranged from 51.1% to 80.9%, the compressive strength ranged from 10.0 to 0.6 MPa, the compressive modulus ranged from 14.9 to 12.1 MPa, and the compressive yield strength ranged from 4.25 to 0.42 MPa. These values, while being in the lower range of reported values for trabecular bone, are the highest reported for PCL scaffolds produced by SLS and are among the highest reported for similar PCL scaffolds produced through other layered manufacturing techniques. Finite element analysis showed good agreement between experimental and computed effective tensile and compressive moduli. Thus, the construction of bone tissue engineering scaffolds endowed with oriented porous architectures and with predictable mechanical properties through SLS is demonstrated.
机译：本文报道了通过选择性激光烧结制备的固体聚己内酯（PCL）和具有一维，二维和三维正交，周期性多孔结构的多孔PCL支架的拉伸和压缩力学性能的实验测定和有限元建模（SLS）。 PCL脚手架是使用最佳工艺参数构建的，可确保脚手架在设计的实体区域中具有几乎全密度（> 95％），并具有出色的几何和尺寸控制（在设计的3-8％之内）。块状PCL的抗张强度为10.5至16.1 MPa，其模量为343.9至364.3 MPa，抗张屈服强度为8.2至10.1 MPa。这些值与通过各种制造方法处理的PCL的报道文献值一致。整个孔隙率为56.87％至83.3％，抗张强度为4.5至1.1 MPa，抗张模量为140.5至35.5 MPa，屈服强度为3.2至0.76 MPa。大块PCL的抗压强度为38.7 MPa，压缩模量为297.8至317.1 MPa，抗压屈服强度为10.3至12.5 MPa。整个孔隙率为51.1％至80.9％，抗压强度为10.0至0.6 MPa，抗压模量为14.9至12.1 MPa，抗压屈服强度为4.25至0.42 MPa。这些值虽然在小梁骨的报道值的较低范围内，但却是SLS生产的PCL支架的最高报道，并且是通过其他分层制造技术生产的类似PCL支架的最高报道。有限元分析表明，在实验和计算的有效拉伸和压缩模量之间有很好的一致性。因此，证明了具有定向多孔结构并具有通过SLS可预测的机械性能的骨组织工程支架的构造。

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