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首页> 外文期刊>Acta biomaterialia >Peri-implant and systemic release of metallic elements following insertion of a mandibular modular endoprosthesis in Macaca fascicularis.
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Peri-implant and systemic release of metallic elements following insertion of a mandibular modular endoprosthesis in Macaca fascicularis.

机译：在Macaca fascicularis中插入下颌模块化内假体后，金属元素的周围植入和全身释放。

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The aim of this study was to assess the release of metal elements from a Ti6Al4V modular endoprosthesis for mandibular reconstruction. Ten monkeys were included, seven of the animals had an endoprosthesis inserted and three served as controls. Mucosa, regional lymph nodes and distant organs, were assessed after the implant had been in place for 12 months, using light (LM) and transmission electron microscopy (TEM) and inductively coupled plasma optical emission spectroscopy (ICP). Blood was also drawn from all animals for elemental analysis using ICP. LM and TEM evaluation showed no detectable metal particles in the mucosa surrounding the endoprosthesis, nor in the regional lymph nodes and distant organs. Blood analysis revealed that titanium and vanadium were detectable in comparable amounts in the test (Ti: 1.63+/-0.54, Va: 0.42+/-0.08) as well as in the control group (Ti: 2.07+/-0.55, Va: 0.37+/-0.07). The amount of aluminum appeared to be higher in the control group (31.77+/-11.67) compared with the test group (20.41+/-9.13), but this difference was not statistically significant. ICP showed that no titanium, vanadium or aluminum was detectable in the mucosa surrounding the endoprosthesis. In addition, no titanium and vanadium were found in the lymph nodes and distant organs using ICP. On the other hand, using ICP, the aluminum content was found to be higher in the right regional lymph nodes and all examined distant organs as compared to the control group (lymph nodes: 11.55+/-22.15 vs. 0.36+/-0.61, lung: 6.24+/-11.28 vs. 1.40+/-2.15, liver: 1.66+/-0.99 vs. 0, kidney: 15.69+/-24.88 vs 0, spleen: 2.75+/-3.09 vs. 0.49+/-0.43). However, only for the kidney and liver the higher amount of aluminum was statistically significant. In conclusion, this study quantified the release of only aluminum in lymph nodes and distant organs, when using a modular endoprosthesis made of Ti-6Al-4V for mandibular reconstruction.
机译：这项研究的目的是评估从Ti6Al4V模块化内置假体中进行下颌骨重建的金属元素的释放。包括十只猴子，其中七只动物插入了假体，三只作为对照。使用光（LM）和透射电子显微镜（TEM）以及电感耦合等离子体发射光谱（ICP）对植入物放置12个月后的黏膜，局部淋巴结和远处器官进行评估。还从所有动物中抽血以使用ICP进行元素分析。 LM和TEM评估显示，在假体周围的粘膜中，在区域淋巴结和远处的器官中均未检测到金属颗粒。血液分析显示，在测试中（Ti：1.63 +/- 0.54，Va：0.42 +/- 0.08）和对照组（Ti：2.07 +/- 0.55，Va： 0.37 +/- 0.07）。对照组（31.77 +/- 11.67）的铝含量似乎高于测试组（20.41 +/- 9.13），但这一差异在统计学上并不显着。 ICP显示，在假体周围的粘膜中未检测到钛，钒或铝。此外，使用ICP在淋巴结和远处器官中均未发现钛和钒。另一方面，使用ICP，与对照组相比，右侧区域淋巴结和所有检查的远处器官的铝含量均高于对照组（淋巴结：11.55 +/- 22.15与0.36 +/- 0.61，肺：6.24 +/- 11.28 vs.1.40 +/- 2.15，肝脏：1.66 +/- 0.99 vs.0，肾脏：15.69 +/- 24.88 vs.0，脾脏：2.75 +/- 3.09 vs. 0.49 +/- 0.43 ）。但是，仅对于肾脏和肝脏，较高的铝含量具有统计学意义。总之，当使用由Ti-6Al-4V制成的模块化内置假体进行下颌骨重建时，本研究量化了仅铝在淋巴结和远处器官中的释放。

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