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首页> 外文期刊>Acta biomaterialia >Impact of bone geometry on effective properties of bone scaffolds.
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Impact of bone geometry on effective properties of bone scaffolds.

机译：骨几何形状对骨支架有效特性的影响。

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The characterization of bone/scaffold composite mechanical properties is essential for translation to the clinic, but in vivo studies require resources and personnel not available to many investigators. Therefore, the ability to predict composite properties could facilitate scaffold evaluation and reduce the number of in vivo studies required. To date, there have been no studies that have used experimental data to formulate a model of bone morphology or that have examined morphology as a variable in composite properties. In this study, a simple model was developed to predict the effective elastic properties of hydroxyapatite (HA) scaffold/bone composites using representative volume elements (RVE) and finite element analysis. While the RVE for the scaffold is clear, the choice of RVE for bone is not. Two bone geometries were generated for the RVE based on data from an in vivo study: a uniform coating and bridges in pores. Three scaffolds were evaluated in order to consider the effects of scaffold material modulus and porosity. Results showed that the bone geometry had little influence on composite elastic properties when compared to experimental error from the in vivo study. The implication is that such properties can be estimated by measuring the volume fraction of bone using a non-destructive method like microcomputerized tomography and the simple RVE model.
机译：骨/支架复合材料机械性能的表征对于临床翻译至关重要，但是体内研究需要许多研究人员无法获得的资源和人员。因此，预测复合材料性能的能力可以促进支架评估并减少所需的体内研究次数。迄今为止，还没有研究使用实验数据来建立骨骼形态模型或研究形态作为复合材料特性变量的研究。在这项研究中，使用代表性的体积元素（RVE）和有限元分析方法，开发了一个简单的模型来预测羟基磷灰石（HA）脚手架/骨复合材料的有效弹性性能。尽管支架的RVE很明确，但骨骼的RVE的选择却不清楚。基于体内研究的数据，为RVE生成了两种骨骼几何形状：均匀的涂层和孔中的桥。为了考虑支架材料的模量和孔隙率的影响，对三个支架进行了评估。结果表明，与体内研究的实验误差相比，骨骼的几何形状对复合材料的弹性几乎没有影响。这意味着可以通过使用非破坏性方法（如微型计算机断层扫描和简单的RVE模型）测量骨骼的体积分数来估计这些属性。

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