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首页> 外文期刊>Acta biomaterialia >Poly(lactic-co-glycolic acid) electrospun fibrous meshes for the controlled release of retinoic acid.
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Poly(lactic-co-glycolic acid) electrospun fibrous meshes for the controlled release of retinoic acid.

机译：聚乳酸-乙醇酸电纺纤维网，用于视黄酸的控制释放。

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摘要

Poly(lactic-co-glycolic acid) (PLGA) meshes loaded with retinoic acid (RA) were prepared by applying the electrospinning technique. The purpose of the present work was to combine the biological effects of RA and the advantages of electrospun meshes to enhancing the mass transfer features of controlled release systems and cell interaction with polymeric scaffolds. The processing conditions for the fabrication of three-dimensional meshes were optimized by studying their influence on mesh morphology. Tensile testing showed that RA loading influenced the meshes' mechanical properties by increasing their strength and rigidity. Moreover, the drug release and degradation profiles of the electrospun systems were compared to analogous RA-loaded PLGA films prepared by solvent casting. The results of this study highlight that the electrospun meshes preserved their fibrous structure after 4 months under in vitro physiological conditions and showed a sustained controlled release of the loaded agent in comparison to that observed for cast films. The bioactivity of the loaded RA was investigated on murine preosteoblasts cells by evaluating its influence on cell proliferation and morphology.
机译：通过应用静电纺丝技术制备了装有视黄酸（RA）的聚乳酸-乙醇酸共聚物（PLGA）网。本工作的目的是结合RA的生物学效应和电纺网片的优点，以增强控释系统的传质特征以及细胞与聚合物支架的相互作用。通过研究三维网格物体对网格形态的影响，优化了其加工条件。拉伸测试表明，RA载荷通过增加网格的强度和刚度来影响网格的机械性能。此外，将电纺系统的药物释放和降解曲线与通过溶剂流延制备的类似RA负载的PLGA膜进行了比较。这项研究的结果表明，电纺网在体外生理条件下4个月后仍能保持其纤维结构，并且与流延膜相比观察到了负载剂的持续受控释放。通过评估其对细胞增殖和形态的影响，研究了负载的RA对鼠成骨细胞的生物活性。

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