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首页> 外文期刊>Acta biomaterialia >Design of a pseudo-physiological test bench specific to the development of biodegradable metallic biomaterials.
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Design of a pseudo-physiological test bench specific to the development of biodegradable metallic biomaterials.

机译：专为可生物降解的金属生物材料的开发设计的假生理测试台。

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摘要

Endovascular stents have proven effective in treating coronary and peripheral arterial occlusions. Since the first attempts, metals used to make these devices have been generally selected, and designed to be highly resistant to corrosion. Therefore, as almost the totality of metallic biomaterials, they are implanted on a long-term basis. However, complications associated with permanent stents, such as in-stent restenosis and thrombosis, have often been reported. In order to reduce those complications, it would be clinically useful to develop a new family of degradable stents. An interesting material for fabrication of degradable stents is based on magnesium, an essential element involved in human metabolism. Success in using magnesium alloys for the fabrication of endovascular devices is closely related to the properties of the selected alloy. In this context, a test bench was specifically designed to reproduce the physiological conditions to which stents are submitted when implanted in the coronary arteries. Then the test bench was validated using a magnesium-based alloy. Results showed that the corrosion rate and the corrosion mechanisms vary with the applied shear stress and that corrosion products strongly depend on the composition of the corrosive solution. This test bench will thus be useful in further investigations for the development of metallic alloys as degradable biomaterials.
机译：血管内支架已被证明可有效治疗冠状动脉和周围动脉阻塞。自首次尝试以来，通常已经选择了用于制造这些设备的金属，并设计为高度耐腐蚀。因此，几乎所有金属生物材料都需要长期植入。然而，常有报道与永久性支架相关的并发症，如支架内再狭窄和血栓形成。为了减少这些并发症，开发一种新的可降解支架家族在临床上将是有用的。制造可降解支架的一种有趣材料是基于镁，镁是人体新陈代谢的必需元素。使用镁合金制造血管内装置的成功与所选合金的性能密切相关。在这种情况下，专门设计了一个测试台，以再现植入冠状动脉时支架所要满足的生理条件。然后使用镁基合金对测试台进行了验证。结果表明，腐蚀速率和腐蚀机理随所施加的剪切应力而变化，腐蚀产物在很大程度上取决于腐蚀性溶液的组成。因此，该试验台将有助于进一步研究可降解生物材料金属合金的开发。

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