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首页> 外文期刊>Acta biomaterialia >Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties.
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Segmented poly(esterurethane urea)s from novel urea-diol chain extenders: Synthesis, characterization and in vitro biological properties.

机译：新型脲-二醇扩链剂的分段聚（氨基甲酸酯脲）：合成，表征和体外生物学特性。

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摘要

This work describes the preparation, physicochemical characterization, mechanical properties and in vitro biological properties of two bioresorbable aliphatic segmented poly(esterurethane urea)s (SPEUU) based on poly(epsilon-caprolactone) diol (PCL diol), 1,6-hexamethylene diisocyanate and two novel urea-diol chain extenders. To strengthen the interactions through hydrogen bonding in the hard segments of SPEUU, novel chain extenders containing urea groups were synthesized and used in the SPEUU formulation. The different chemical structures of the chain extenders modulated the phase separation of soft and hard segments, as demonstrated by the thermal behavior. The hard segment association was enhanced using a diurea-diol chain extender. The biological interactions between the obtained materials and blood were studied by in vitro methods. Research on the protein adsorption, platelet adhesion and thrombus formation is presented. Studies of protein adsorption onto polymeric surfaces showed that SPEUU adsorbed more albumin than fibrinogen. Studies on platelet adhesion and thrombus formation of SPEUU-coated coverslips indicated the antithrombogenic behavior of these surfaces. The synthesized SPEUU revealed no signs of cytotoxicity to Chinese hamster ovary cells, showing satisfactory cytocompatibility.
机译：这项工作描述了两种基于聚ε-己内酯二醇（PCL二醇），1,6-六亚甲基二异氰酸酯的可生物吸收的脂族链段聚（氨基甲酸酯脲）（SPEUU）的制备，理化特性，力学性能和体外生物学性能。和两种新型脲-二醇扩链剂。为了通过SPEUU硬段中的氢键加强相互作用，合成了含有脲基的新型扩链剂，并将其用于SPEUU配方中。扩链剂的不同化学结构调节了软链段和硬链段的相分离，如热行为所示。使用二脲-二醇扩链剂增强了硬链段缔合。通过体外方法研究了所得材料与血液之间的生物学相互作用。提出了蛋白质吸附，血小板粘附和血栓形成的研究。对蛋白质吸附到聚合物表面的研究表明，SPEUU吸附的白蛋白比纤维蛋白原多。对SPEUU涂层盖玻片的血小板粘附和血栓形成的研究表明了这些表面的抗血栓形成行为。合成的SPEUU没有显示出对中国仓鼠卵巢细胞的细胞毒性迹象，显示出令人满意的细胞相容性。

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