• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Influences of tensile load on in vitro degradation of an electrospun poly(L-lactide-co-glycolide) scaffold.
【24h】

Influences of tensile load on in vitro degradation of an electrospun poly(L-lactide-co-glycolide) scaffold.

机译：拉伸载荷对电纺聚（L-丙交酯-乙交酯）支架体外降解的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Scaffolds for tissue engineering and regenerative medicine are usually subjected to different mechanical loads during in vitro and in vivo degradation. In this study, the in vitro degradation process of electrospun poly(L-lactide-co-glycolide) (PLGA) scaffolds was examined under continuous tensile load and compared with that under no load. As PLGA degraded in phosphate-buffered saline solution (pH 7.4) at 37 degrees C over a 7-week period, the tensile elastic modulus and ultimate strength of the loaded specimen increased dramatically, followed by a decrease, which was much faster than that of the unloaded specimen, whereas break elongation of the loaded samples declined more quickly over the whole degradation period. Moreover, molecular weight, thermal properties and lactic acid release showed greater degradation under load. Also, a ruptured morphology was more obvious after degradation under tensile load. The results demonstrate that tensile load increased the degradation rate of electrospun PLGA and it may be necessary to consider the effects of mechanical load when designing or applying biodegradable scaffolds. Finally, some possible explanation for the faster degradation under load is given.
机译：用于组织工程和再生医学的支架通常在体外和体内降解过程中承受不同的机械负荷。在这项研究中，电纺聚（L-丙交酯-乙交酯）（PLGA）支架的体外降解过程在连续拉伸载荷下进行了检查，并与无载荷下的进行了比较。随着PLGA在37摄氏度的磷酸盐缓冲盐溶液（pH 7.4）中在7周内降解，加载样品的拉伸弹性模量和极限强度急剧上升，随后下降，其下降速度比PGA快得多。卸载样品，而在整个降解期间，加载样品的断裂伸长率下降更快。此外，分子量，热性能和乳酸释放在负载下显示出更大的降解。另外，在拉伸载荷下降解后，断裂形态更加明显。结果表明，拉伸载荷增加了电纺PLGA的降解速率，在设计或应用可生物降解支架时可能需要考虑机械载荷的影响。最后，给出了在负载下更快降解的一些可能解释。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号