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首页> 外文期刊>Acta biomaterialia >Protein interactions with nanoporous sol-gel derived bioactive glasses.
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Protein interactions with nanoporous sol-gel derived bioactive glasses.

机译：蛋白质与纳米多孔溶胶凝胶衍生的生物活性玻璃的相互作用。

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摘要

Sol-gel derived bioactive glasses are excellent candidates for bone regenerative implant materials as they bond with bone, stimulate bone growth and degrade in the body. Their interactions with proteins are critical to understanding their performance after implantation. This study focuses on the interactions between fibrinogen and sol-gel glass particles of the 70S30C (70 mol.% SiO(2), 30 mol.% CaO composition). Sol-gel silica and melt-derived Bioglass(R) were also used for comparison. Fibrinogen penetration into the nanoporous glasses was observed by live tracking the fluorescent-labelled fibrinogen with confocal microscopy. The effect of pore size on protein penetration was investigated. Nanoporous networks with modal pore diameters larger than 6 nm were accessible to fibrinogen. When the modal nanopore diameter was decreased to 2 nm or less, the penetration of fibrinogen was inhibited. The surface properties of the glasses, which can be modulated by media pH, glass composition and final stabilisation temperature in the sol-gel process, have effects on fibrinogen adsorption via long-range Coulombic forces before the adsorption and via short-range interactions such as hydrogen bonding after the adsorption.
机译：溶胶-凝胶衍生的生物活性玻璃是骨再生植入物材料的极佳候选者，因为它们与骨骼结合，刺激骨骼生长并在体内降解。它们与蛋白质的相互作用对于了解植入后的性能至关重要。这项研究的重点是70S30C（70摩尔％SiO（2），30摩尔％CaO组成）和纤维蛋白原与溶胶-凝胶玻璃颗粒之间的相互作用。溶胶-凝胶二氧化硅和熔融衍生的Bioglass也用于比较。通过共聚焦显微镜实时跟踪荧光标记的纤维蛋白原，观察到纤维蛋白原渗透到纳米孔玻璃中。研究了孔径对蛋白质渗透的影响。纤维蛋白原可接近具有大于6nm的模态孔径的纳米孔网络。当模态纳米孔直径减小到2nm或更小时，纤维蛋白原的渗透被抑制。玻璃的表面特性可以通过介质pH，玻璃组成和溶胶-凝胶过程中的最终稳定温度来调节，它们通过吸附前的长距离库仑力和短程相互作用（例如：吸附后氢键结合。

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