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首页> 外文期刊>Acta biomaterialia >Phospholipid bilayer formation on a variety of nanoporous oxide and organic xerogel films.
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Phospholipid bilayer formation on a variety of nanoporous oxide and organic xerogel films.

机译：在各种纳米多孔氧化物和有机干凝胶薄膜上形成磷脂双层。

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摘要

Lipid bilayers supported by nanoporous xerogel materials are being explored as models for cell membranes. In order to better understand and characterize the nature of the surface-bilayer interactions, several oxide and organic nanoporous xerogel films (alumina, titania, iron oxide, phloroglucinol-formaldehyde, resorcinol-formaldehyde and cellulose acetate) have been investigated as a scaffold for vesicle-fused 1,2-dioleoyl-glycero-3-phosphocholine (DOPC) lipid bilayer formation and mobility. The surface topography of the different substrates was analyzed using contact and tapping-mode atomic force microscopy and the surface energy of the substrates was determined using contact angle goniometry. Lipid bilayer formation has been observed with fluorescence microscopy and lateral lipid diffusion coefficients have been determined using fluorescence recovery after photobleaching. Titania xerogel films were found to be a robust and convenient support for formation of a two-phase DOPC/1,2-distearoyl-glycero-3-phosphocholine bilayer and domains were observed with this system. It was found that the cellulose acetate xerogel film support produced the slowest lipid lateral diffusion.
机译：由纳米多孔干凝胶材料支持的脂质双层正在探索作为细胞膜的模型。为了更好地理解和表征表面-双层相互作用的性质，已经研究了几种氧化物和有机纳米多孔凝胶膜（氧化铝，二氧化钛，氧化铁，间苯三酚-甲醛，间苯二酚-甲醛和乙酸纤维素）作为囊泡的支架。融合的1,2-二油酰基-甘油-3-磷酸胆碱（DOPC）脂质双层形成和迁移。使用接触和分接模式原子力显微镜分析不同基材的表面形貌，并使用接触角测角法确定基材的表面能。用荧光显微镜观察到了脂质双层的形成，并且使用了光漂白后的荧光回收率测定了脂质的横向扩散系数。发现二氧化钛干凝胶膜是形成两相DOPC / 1,2-二硬脂酰基-甘油-3-磷酸胆碱双层的有力且方便的载体，并且在该系统中观察到了畴。发现乙酸纤维素干凝胶膜载体产生最慢的脂质横向扩散。

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