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首页> 外文期刊>Acta biomaterialia >Dynamic mechanical analysis and biomineralization of hyaluronan-polyethylene copolymers for potential use in osteochondral defect repair.
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Dynamic mechanical analysis and biomineralization of hyaluronan-polyethylene copolymers for potential use in osteochondral defect repair.

机译：透明质酸-聚乙烯共聚物的动态力学分析和生物矿化，潜在地用于骨软骨缺损修复。

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摘要

Treatment options for damaged articular cartilage are limited due to its lack of vasculature and its unique viscoelastic properties. This study was the first to fabricate a hyaluronan (HA)-polyethylene copolymer for potential use in the replacement of articular cartilage and repair of osteochondral defects. Amphiphilic graft copolymers consisting of HA and high-density polyethylene (HA-co-HDPE) were fabricated with 10, 28 and 50 wt.% HA. Dynamic mechanical analysis was used to assess the effect of varying constituent weight ratios on the viscoelastic properties of HA-co-HDPE materials. The storage moduli of HA-co-HDPE copolymers ranged from 2.4 to 15.0 MPa at physiological loading frequencies. The viscoelastic properties of the HA-co-HDPE materials were significantly affected by varying the wt.% of HA and/or crosslinking of the HA constituent. Cytotoxicity and the ability of the materials to support mineralization were evaluated in the presence of bone marrow stromal cells. HA-co-HDPE materials were non-cytotoxic, and calcium and phosphorus were present on the surface of the HA-co-HDPE materials 2 weeks after osteogenic differentiation of the bone marrow stromal cells. This study is the first to measure the viscoelastic properties and osseocompatibility of HA-co-HDPE for potential use in orthopedic applications.
机译：受损的关节软骨缺乏血管系统和独特的粘弹性质，因此治疗方法受到限制。这项研究是第一个制造透明质酸（HA）-聚乙烯共聚物的研究，可用于替代关节软骨和修复骨软骨缺损。由HA和高密度聚乙烯（HA-co-HDPE）组成的两亲接枝共聚物是用10、28和50 wt％的HA制成的。使用动态力学分析来评估不同组成重量比对HA-co-HDPE材料粘弹性的影响。 HA-co-HDPE共聚物在生理负载频率下的储能模量为2.4到15.0 MPa。通过改变HA的重量％和/或HA组分的交联，HA-co-HDPE材料的粘弹性能受到显着影响。在存在骨髓基质细胞的情况下，评估了细胞毒性和材料支持矿化的能力。 HA-co-HDPE材料无细胞毒性，在骨髓基质细胞成骨分化2周后，HA-co-HDPE材料的表面存在钙和磷。这项研究是首次测量HA-co-HDPE的粘弹性和骨相容性，可用于整形外科领域。

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