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首页> 外文期刊>Acta biomaterialia >Nanofibrillated cellulose composite hydrogel for the replacement of the nucleus pulposus.
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Nanofibrillated cellulose composite hydrogel for the replacement of the nucleus pulposus.

机译：纳米原纤化纤维素复合水凝胶，用于置换髓核。

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摘要

The swelling and compressive mechanical behavior as well as the morphology and biocompatibility of composite hydrogels based on Tween(R) 20 trimethacrylate (T3), N-vinyl-2-pyrrolidone (NVP) and nanofibrillated cellulose (NFC) were assessed in the present study. The chemical structure of T3 was verified by Fourier transform infrared spectroscopy and proton nuclear magnetic resonance, and the degree of substitution was found to be around 3. Swelling ratios of neat hydrogels composed of different concentrations of T3 and NVP were found to range from 1.5 to 5.7 with decreasing concentration of T3. Various concentrations of cellulose nanofibrils (0.2-1.6wt.%) were then used to produce composite hydrogels that showed lower swelling ratios than neat ones for a given T3 concentration. Neat and composite hydrogels exhibited a typical nonlinear response under compression. All composite hydrogels showed an increase in elastic modulus compared to neat hydrogel of about 3- to 8-fold, reaching 18kPa at 0% strain and 62kPa at 20% strain for the hydrogel with the highest NFC content. All hydrogels presented a porous and homogeneous structure, with interconnected pore cells of around 100nm in diameter. The hydrogels are biocompatible. The results of this study demonstrate that composite hydrogels reinforced with NFC may be viable as nucleus pulposus implants due to their adequate swelling ratio, which may restore the annulus fibrosus loading, and their increased mechanical properties, which could possibly restore the height of the intervertebral discs.
机译：在本研究中评估了基于Tween（R）20三甲基丙烯酸酯（T3），N-乙烯基-2-吡咯烷酮（NVP）和纳米原纤化纤维素（NFC）的复合水凝胶的溶胀和压缩力学行为以及形态和生物相容性。 。通过傅里叶变换红外光谱和质子核磁共振验证了T3的化学结构，发现其取代度约为3。发现由不同浓度的T3和NVP组成的纯净水凝胶的溶胀比范围为1.5至1.5。 5.7随着T3浓度的降低。然后使用各种浓度的纤维素纳米原纤维（0.2-1.6wt。％）来生产复合水凝胶，在给定的T3浓度下，其溶胀率比纯净的凝胶低。纯净的和复合的水凝胶在压缩下表现出典型的非线性响应。与纯净水凝胶相比，所有复合水凝胶均显示出约3至8倍的弹性模量增加，对于NFC含量最高的水凝胶，在0％应变时达到18kPa，在20％应变时达到62kPa。所有水凝胶均呈现出多孔且均质的结构，并具有直径约100nm的相互连接的孔隙。水凝胶是生物相容的。这项研究的结果表明，由于NFC增强的复合水凝胶具有足够的溶胀率，因此可以作为髓核植入物使用，从而可以恢复纤维环的负荷，并提高其机械性能，从而可以恢复椎间盘的高度。

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