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首页> 外文期刊>Acta biomaterialia >Direct ink writing of highly porous and strong glass scaffolds for load-bearing bone defects repair and regeneration.
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Direct ink writing of highly porous and strong glass scaffolds for load-bearing bone defects repair and regeneration.

机译：直接墨水书写的多孔性强的玻璃支架，用于承重的骨缺损的修复和再生。

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摘要

The quest for synthetic materials to repair load-bearing bone lost because of trauma, cancer, or congenital bone defects requires the development of porous, high-performance scaffolds with exceptional mechanical strength. However, the low mechanical strength of porous bioactive ceramic and glass scaffolds, compared with that of human cortical bone, has limited their use for these applications. In the present work bioactive 6P53B glass scaffolds with superior mechanical strength were fabricated using a direct ink writing technique. The rheological properties of Pluronic(R) F-127 (referred to hereafter simply as F-127) hydrogel-based inks were optimized for the printing of features as fine as 30 mum and of three-dimensional scaffolds. The mechanical strength and in vitro degradation of the scaffolds were assessed in a simulated body fluid (SBF). The sintered glass scaffolds showed a compressive strength (136 +/- 22 MPa) comparable with that of human cortical bone (100-150 MPa), while the porosity (60%) was in the range of that of trabecular bone (50-90%). The strength is ~100-times that of polymer scaffolds and 4-5-times that of ceramic and glass scaffolds with comparable porosities. Despite the strength decrease resulting from weight loss during immersion in SBF, the value (77 MPa) is still far above that of trabecular bone after 3 weeks. The ability to create both porous and strong structures opens a new avenue for fabricating scaffolds for load-bearing bone defect repair and regeneration.
机译：寻求合成材料来修复由于外伤，癌症或先天性骨缺损而失去的承重骨的需求，要求开发具有优异机械强度的多孔，高性能支架。然而，与人类皮质骨相比，多孔生物活性陶瓷和玻璃支架的机械强度低，限制了它们在这些应用中的用途。在本工作中，使用直接墨水书写技术制造了具有优异机械强度的生物活性6P53B玻璃支架。对F-127（以下简称为F-127）水凝胶基油墨的流变性质进行了优化，以印刷30毫米以下的精细特征和三维支架。在模拟体液（SBF）中评估了支架的机械强度和体外降解。烧结玻璃支架的抗压强度（136 +/- 22 MPa）与人皮质骨（100-150 MPa）相当，而孔隙率（60％）在小梁骨（50-90）范围内％）。强度约为聚合物支架的100倍，是孔隙率相当的陶瓷和玻璃支架的4-5倍。尽管浸泡在SBF中会因重量减轻而导致强度下降，但3周后该值（77 MPa）仍远高于小梁骨。同时产生多孔结构和坚固结构的能力为制造用于承重骨缺损修复和再生的支架制造开辟了一条新途径。

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