首页> 外文期刊>Acta biomaterialia >Ag and Ag/N2 plasma modification of polyethylene for the enhancement of antibacterial properties and cell growth/proliferation.
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Ag and Ag/N2 plasma modification of polyethylene for the enhancement of antibacterial properties and cell growth/proliferation.

机译:聚乙烯的Ag和Ag / N2等离子体改性,以增强抗菌性能和细胞生长/增殖。

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摘要

Polyethylene (PE) is one of the most common materials used for medical implants. However, it usually possesses low biocompatibility and insufficient antibacterial properties. In the work described here, plasma immersion ion implantation (PIII) is employed to implant silver into PE to enhance both its antibacterial properties and its biocompatibility. Our results show that Ag PIII can give rise to excellent antibacterial properties and induces the formation of functional groups such as C-O and C=C. These C-O and C=C groups on the modified surface can trigger the growth of the human fetal osteoblastic cell line (hFOB). Furthermore, combining N(2) and Ag PIII prolongs the antibacterial effects, but nitrogen-containing functional groups such as C-N and C=N created by N(2) co-PIII negatively impact proliferation of hFOB on the surface. According to our experimental investigation on cell proliferation, functional groups such as C-N and C=N created by nitrogen PIII are disadvantageous to cell growth whereas the C-O and C=C groups benefit cell growth. Both the antibacterial activity and biocompatibility of PE can be enhanced by means of the proper plasma surface treatment.
机译:聚乙烯(PE)是用于医疗植入物的最常见材料之一。然而,它通常具有低的生物相容性和不足的抗菌性能。在此处描述的工作中,采用等离子体浸没离子注入(PIII)将银注入PE中,以增强其抗菌性能和生物相容性。我们的结果表明,Ag PIII可以产生出色的抗菌性能并诱导形成C-O和C = C等官能团。修饰表面上的这些C-O和C = C基团可以触发人胎儿成骨细胞系(hFOB)的生长。此外,将N(2)和Ag PIII结合使用可延长抗菌效果,但是N(2)co-PIII创建的含氮官能团(例如C-N和C = N)会对hFOB在表面的增殖产生负面影响。根据我们对细胞增殖的实验研究,由氮PIII产生的C-N和C = N等官能团不利于细胞生长,而C-O和C = C则有利于细胞生长。通过适当的血浆表面处理,可以增强PE的抗菌活性和生物相容性。

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