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首页> 外文期刊>Acta biomaterialia >Fabrication of poly- DL-lactide/polyethylene glycol scaffolds using the gas foaming technique
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Fabrication of poly- DL-lactide/polyethylene glycol scaffolds using the gas foaming technique

机译：使用气体发泡技术制备聚DL-丙交酯/聚乙二醇支架

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The aim of this study was to prepare poly- DL-lactide/ polyethylene glycol (P DLLA/PEG) blends to improve medium absorption and cell proliferation in the three-dimensional (3-D) structure of their scaffolds. Carbon dioxide (CO 2) was used as a foaming agent to create porosity in these blends. The results of Fourier transform infrared (FTIR) spectroscopy demonstrated that the blends were homogeneous mixtures of P DLLA and PEG. The peak shifts at 1092 and 1744 cm -1 confirmed the presence of molecular interactions between these two compounds. Increasing the PEG weight ratio enhanced the relative crystallinity and hydrophilicity. The P DLLA/PEG blends (especially 80/20 and 70/30 weight ratios) exhibited linear degradation profiles over an incubation time of 8 weeks. The mechanical properties of P DLLA/PEG blends having less than 30 wt.% PEG were suitable for the fabrication of porous scaffolds. Increasing the concentration of PEG to above 50% resulted in blends that were brittle and had low mechanical integrity. Highly porous scaffolds with controllable pore size were produced for 30 wt.% PEG samples using the gas foaming technique at temperatures between 25 and 55 °C and pressures between 60 and 160 bar. The average pore diameters achieved by gas foaming process were between 15 and 150 μm, and had an average porosity of 84%. The medium uptake and degradation rate of fabricated P DLLA/PEG scaffolds were increased compared with neat P DLLA film due to the presence of PEG and porosity. The porous scaffolds also demonstrated a lower modulus of elasticity and a higher elongation at break compared to the non-porous film. The fabricated P DLLA/PEG scaffolds have high potential for various tissue-engineering applications. Crown
机译：这项研究的目的是制备聚DL-丙交酯/聚乙二醇（P DLLA / PEG）共混物，以改善其支架的三维（3-D）结构中的培养基吸收和细胞增殖。二氧化碳（CO 2）被用作发泡剂以在这些混合物中产生孔隙。傅里叶变换红外（FTIR）光谱的结果表明，共混物是P DLLA和PEG的均质混合物。在1092和1744 cm -1处的峰位移证实了这两种化合物之间存在分子相互作用。增加PEG重量比可提高相对结晶度和亲水性。 P DLLA / PEG共混物（特别是80/20和70/30的重量比）在8周的孵育时间内显示出线性降解曲线。具有小于30重量％PEG的P DLLA / PEG共混物的机械性能适合于多孔支架的制造。将PEG的浓度增加到50％以上会导致混合物变脆，机械完整性低。使用气体发泡技术在25至55°C的温度和60至160 bar的压力下，为30 wt。％PEG样品生产了具有可控制孔径的高度多孔支架。通过气体发泡过程获得的平均孔径在15和150μm之间，并且具有84％的平均孔隙率。与纯P DLLA薄膜相比，由于PEG的存在和孔隙率，制成的P DLLA / PEG支架的介质摄取和降解速率增加。与无孔膜相比，多孔支架还表现出较低的弹性模量和较高的断裂伸长率。所制造的P DLLA / PEG支架对于各种组织工程应用具有很高的潜力。王冠

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