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首页> 外文期刊>Acta biomaterialia >Cerasomal doxorubicin with long-term storage stability and controllable sustained release
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Cerasomal doxorubicin with long-term storage stability and controllable sustained release

机译：具有长期储存稳定性和可控缓释的阿霉素阿霉素

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摘要

Liposomal nanohybrid cerasomes display a remarkable ability to maintain their size and retain encapsulated doxorubicin (DOX) over a period of 90 days under storage conditions in solution compared with liposomes and liposils. Cerasomes retained 92.1 ± 2.9% of the drug payload after 90 days storage, much more than liposomes (35.2 ± 2.5%) and liposils (53.2 ± 5.5%). Under physiologically relevant conditions cerasomes exhibit a low initial burst in the first 5 h and subsequent sustained release of DOX over the next 150 h. Moreover, the magnitude of the initial burst and the rate of sustained release of DOX from cerasomes can be modulated by incorporating dipalmitoylphosphatidylglycerol (DPPG) in the cerasome structure and altering the ratios of the cerasome-forming lipid and phospholipids. Consequently, a wide range of release profiles can be achieved by altering the vesicle composition. Finally, human ovarian cancer cells are effectively killed by DOX released from cerasomes. Together these results suggest that cerasomes may be a promising drug delivery system for the long-term storage and controllable sustained release of the anticancer drug DOX.
机译：与脂质体和脂质体相比，脂质体纳米混合体在溶液中于储存条件下在90天的时间内显示出显着的能力来保持其大小并保留封装的阿霉素（DOX）。储存90天后，陶瓷小体保留了92.1±2.9％的药物有效负载，远远超过脂质体（35.2±2.5％）和脂质体（53.2±5.5％）。在生理相关的条件下，体小体在最初的5小时内显示出较低的初始爆发，随后在接下来的150小时内持续释放DOX。此外，可以通过将二棕榈酰磷脂酰甘油（DPPG）掺入到陶瓷体结构中并改变形成陶瓷体的脂质和磷脂的比例来调节DOX从陶瓷体的初始爆发的幅度和持续释放的速率。因此，可以通过改变囊泡组成来实现宽范围的释放曲线。最后，人类卵巢癌细胞可被从脂质体释放的DOX有效杀死。这些结果共同表明，对于抗癌药DOX的长期储存和可控的持续释放，陶瓷小体可能是一个有前途的药物递送系统。

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