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首页> 外文期刊>Acta biomaterialia >Formulation and characterization of poloxamine-based hydrogels as tissue sealants
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Formulation and characterization of poloxamine-based hydrogels as tissue sealants

机译：泊洛沙明基水凝胶作为组织密封剂的配制与表征

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In situ cross linkable polyethylene glycol (PEG)-based polymers play an increasing role in surgical practice as sealants that provide a barrier to fluid/gas leakage and adhesion formation. This study investigated the gelation behavior and physical properties of hydrogels formed from homogeneous and blended solutions of two acrylated poloxamines (Tetronics? T1107 and T904) of various molecular weights and hydrophilic/lipophilic balances relative to a PEG control. Hydrogels were formed by reverse thermal gelation at physiological temperature (T1107-containing formulations) and covalent crosslinking by Michael-type addition with dithiothreitol. All poloxamine-based hydrogels exhibited thermosensitive behavior and achieved significantly reduced swelling, increased tensile properties and increased tissue bond strength relative to the PEG hydrogel at physiological temperature. Swelling and tensile properties of all poloxamine-based hydrogels were significantly greater at 37 °C relative to 4 °C, suggesting that their improved physical properties derive from cooperative crosslinking by both noncovalent and covalent mechanisms. Poloxamine-based hydrogels were cytocompatible and underwent hydrolytic degradation over 2-5 weeks, depending on their T1107/T904 composition. In conclusion, select poloxamine-based hydrogels possess a number of properties potentially beneficial to tissue sealant applications, including a substantial increase in viscosity between room/physiological temperatures, resistance to cell adhesion and maintenance of a stable volume during equilibration.
机译：原位可交联的基于聚乙二醇（PEG）的聚合物作为密封剂在外科手术中起着越来越重要的作用，它为流体/气体泄漏和粘附形成提供了屏障。这项研究研究了由两种分子量和亲水性/亲脂性平衡的丙烯酸丙烯酸泊洛沙明（Tetronics？T1107和T904）的均质和混合溶液形成的水凝胶的凝胶行为和物理性质，相对于PEG对照。通过在生理温度下逆热凝胶化（含T1107的制剂）并通过与二硫苏糖醇的迈克尔型加成进行共价交联来形成水凝胶。与基于PEG水凝胶的生理温度相比，所有基于poloxamine的水凝胶均表现出热敏性能，并实现了显着降低的溶胀，增强的拉伸性能和增强的组织结合强度。在37°C时，相对于4°C，所有基于poloxamine的水凝胶的溶胀和拉伸性能均明显更高，这表明它们改善的物理性能来自于通过非共价和共价机制的协同交联。基于泊洛沙明的水凝胶具有细胞相容性，并在2-5周内进行水解降解，具体取决于其T1107 / T904的组成。总之，选择的基于泊洛沙明的水凝胶具有许多可能有益于组织密封剂应用的性能，包括室温/生理温度之间的粘度显着增加，对细胞粘附的抵抗力以及在平衡过程中保持稳定的体积。

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