• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Acta biomaterialia >Biodegradable nanocomposite hydrogel structures with enhanced mechanical properties prepared by photo-crosslinking solutions of poly(trimethylene carbonate)-poly(ethylene glycol)-poly(trimethylene carbonate) macromonomers and nanoclay particles
【24h】

Biodegradable nanocomposite hydrogel structures with enhanced mechanical properties prepared by photo-crosslinking solutions of poly(trimethylene carbonate)-poly(ethylene glycol)-poly(trimethylene carbonate) macromonomers and nanoclay particles

机译：通过光交联聚（碳酸三亚甲基酯）-聚（乙二醇）-聚（碳酸三亚甲基酯）大分子单体和纳米粘土颗粒的溶液制备的具有增强的机械性能的可生物降解的纳米复合水凝胶结构

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Soft hydrogels with elasticity modulus values lower than 100 kPa that are tough and biodegradable are of great interest in medicine and in tissue engineering applications. We have developed a series of soft hydrogel structures from different methacrylate-functionalized triblock copolymers of poly(ethylene glycol) (PEG) with poly(trimethylene carbonate) (PTMC) by photo-crosslinking aqueous solutions of the macromonomers in 2.5 and 5 wt.% colloidal dispersions of clay nanoparticles (Laponite XLG). The length of the PTMC blocks of the macromonomers and the clay content determined the physicomechanical properties of the obtained hydrogels. While an increase in the PTMC block length in the macromonomers from 0.2 to 5 kg/mol resulted in a decrease in the gel content, the addition of 5 wt.% Laponite nanoclay to the crosslinking solution lead to very high gel contents of the hydrogels of more than 95%. The effect of PTMC block length on the mechanical properties of the hydrogels was not as pronounced, and soft gels with a compressive modulus of less than 15 kPa and toughness values of 25 kJ m -3 were obtained. However, the addition of 5 wt.% Laponite nanoclay to the formulations considerably increased the compressive modulus and resilience of the hydrogels; swollen nanocomposite networks with compressive modulus and toughness values of up to 67 kPa and 200 kJ m -3, respectively, could then be obtained. The prepared hydrogels were shown to be enzymatically degradable by cholesterol esterase and by the action of macrophages. With an increase in PTMC block length in the hydrogels, the rates of mass loss increased, while the incorporated Laponite nanoclay suppressed degradation. Nanocomposite hydrogel structures with a designed gyroid pore network architecture were prepared by stereolithography. Furthermore, in the swollen state the porous gyroid structures were mechanically stable and the pore network remained fully open and interconnected.
机译：坚韧且可生物降解的弹性模量值低于100 kPa的软水凝胶在医学和组织工程应用中引起了极大的兴趣。我们通过光交联大分子单体在2.5和5 wt。％的水溶液中，从聚乙二醇（PEG）与聚碳酸三亚甲基酯（PTMC）的不同甲基丙烯酸酯官能化的三嵌段共聚物中开发出了一系列软水凝胶结构粘土纳米颗粒的胶态分散体（Laponite XLG）。大分子单体的PTMC嵌段的长度和粘土含量决定了所获得的水凝胶的物理机械性能。大分子单体中PTMC嵌段长度从0.2增至5 kg / mol导致凝胶含量降低，而向交联溶液中添加5 wt％的Laponite纳米粘土会导致水凝胶的凝胶含量非常高。超过95％。 PTMC嵌段长度对水凝胶的机械性能的影响不是很明显，并且获得了具有小于15kPa的压缩模量和25kJ m -3的韧性值的软凝胶。但是，向配方中添加5 wt％的Laponite纳米粘土可显着提高水凝胶的压缩模量和回弹力。然后可获得分别具有高达67kPa和200kJ m -3的压缩模量和韧性值的溶胀的纳米复合网络。所制备的水凝胶经胆固醇酯酶和巨噬细胞的作用可被酶降解。随着水凝胶中PTMC嵌段长度的增加，质量损失率增加，而掺入的Laponite纳米粘土则抑制了降解。通过立体光刻法制备了具有设计的陀螺孔网络结构的纳米复合水凝胶结构。此外，在溶胀状态下，多孔螺旋结构机械稳定，并且孔网络保持完全开放和相互连接。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号