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首页> 外文期刊>Acta biomaterialia >Evaluation of antibiotic releasing porous polymethylmethacrylate space maintainers in an infected composite tissue defect model
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Evaluation of antibiotic releasing porous polymethylmethacrylate space maintainers in an infected composite tissue defect model

机译：感染的复合组织缺损模型中释放抗生素的多孔聚甲基丙烯酸甲酯空间维持剂的评价

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摘要

This study evaluated the in vitro and in vivo performance of antibiotic-releasing porous polymethylmethacrylate (PMMA)-based space maintainers comprising a gelatin hydrogel porogen and a poly(dl-lactic-co- glycolic acid) (PLGA) particulate carrier for antibiotic delivery. Colistin was released in vitro from either gelatin or PLGA microparticle loaded PMMA constructs, with gelatin-loaded constructs releasing colistin over approximately 7 days and PLGA microparticle-loaded constructs releasing colistin for up to 8 weeks. Three formulations with either burst release or extended release at different doses were tested in a rabbit mandibular defect inoculated with Acinetobacter baumannii (2 × 107 colony forming units ml -1). In addition, one material control that released antibiotic but was not inoculated with A. baumannii was tested. A. baumannii was not detectable in any animal after 12 weeks on culture of the defect, saliva, or blood. Defects with high dose extended release implants had greater soft tissue healing compared with defects with burst release implants, with 8 of 10 animals showing healed mucosae compared with 2 of 10 respectively. Extended release of locally delivered colistin via a PLGA microparticle carrier improved soft tissue healing compared with implants with burst release of colistin from a gelatin carrier.
机译：这项研究评估了释放明胶的多孔聚甲基丙烯酸甲酯（PMMA）基空间维持剂的体外和体内性能，该明胶包含明胶水凝胶致孔剂和聚（dl-乳酸-乙醇酸）（PLGA）微粒载体，可用于递送抗生素。共利斯汀从明胶或PLGA微粒负载的PMMA构建体中体外释放，其中明胶负载的构建体在大约7天内释放粘菌素，而PLGA微粒负载的构建体释放粘菌素长达8周。在接种鲍曼不动杆菌（2×107集落形成单位ml -1）的兔下颌缺损中，测试了三种不同剂量的突释或缓释制剂。另外，测试了一种释放抗生素但未接种鲍曼不动杆菌的材料对照。培养缺损，唾液或血液12周后，在任何动物中均未检出鲍曼不动杆菌。与爆发释放植入物的缺陷相比，高剂量延长释放植入物的缺陷具有更好的软组织愈合，每10只动物中有8只表现出粘膜愈合，而每10只动物中有2只表现出愈合。与从明胶载体中突然释放粘菌素的植入物相比，通过PLGA微粒载体延长释放的本地粘菌素的释放改善了软组织的愈合。

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