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首页> 外文期刊>Acta biomaterialia >Adaptable poly(ethylene glycol) microspheres capable of mixed-mode degradation
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Adaptable poly(ethylene glycol) microspheres capable of mixed-mode degradation

机译：具有混合模式降解能力的适应性聚乙二醇微球

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摘要

A simple, degradable poly(ethylene glycol) (PEG) microsphere system formed from a water-in-water emulsion process is presented. Microsphere network degradation and erosion were controlled by adjusting the number of hydrolytically labile sites, by varying the PEG molecular weight, and by adjusting the emulsion conditions. Microsphere size was also controllable by adjusting the polymer formulation. Furthermore, it is demonstrated that alternative degradation and erosion mechanisms, such as proteolytic degradation, can be incorporated into PEG microspheres, resulting in mixed-mode degradation. Owing to the adaptability of this approach, it may serve as an attractive option for emerging tissue engineering, drug delivery and gene delivery applications.
机译：介绍了一种由水包水乳液工艺形成的简单，可降解的聚乙二醇（PEG）微球系统。微球网络的降解和侵蚀可通过调节水解不稳定位点的数量，改变PEG分子量以及调节乳化条件来控制。微球尺寸也可通过调节聚合物配方来控制。此外，已证明可以将替代的降解和侵蚀机制（例如蛋白水解降解）掺入PEG微球中，从而导致混合模式降解。由于这种方法的适应性，它可以作为新兴组织工程，药物递送和基因递送应用的有吸引力的选择。

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