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首页> 外文期刊>Acta biomaterialia >Influence of polymer molecular weight in osteoinductive composites for bone tissue regeneration
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Influence of polymer molecular weight in osteoinductive composites for bone tissue regeneration

机译：骨诱导复合物中聚合物分子量对骨组织再生的影响

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摘要

In bone tissue regeneration, certain polymer and calcium-phosphate-based composites have been reported to enhance some biological surface phenomena, facilitating osteoinduction. Although the crucial role of inorganic fillers in heterotopic bone formation by such materials has been shown, no reports have been published on the potential effects the polymer phase may have. The present work starts from the assumption that the polymer molecular weight regulates the fluid uptake, which determines the hydrolysis rate and the occurrence of biological surface processes. Here, two composites were prepared by extruding two different molecular weight l/d,l-lactide copolymers with calcium phosphate apatite. The lower molecular weight copolymer allowed larger fluid uptake in the composite thereof, which was correlated with a higher capacity to adsorb proteins in vitro. Further, the large fluid absorption led to a quicker composite degradation that generated rougher surfaces and enhanced ion release. Following intramuscular implantation in sheep, only the composite with the lower molecular weight polymer could induce heterotopic bone formation. Besides influencing the biological potential of composites, the molecular weight also regulated their viscoelastic behaviour under cyclic stresses. The results lead to the conclusion that designing biomaterials with appropriate physico-chemical characteristics is crucial for bone tissue regeneration in mechanical load-bearing sites.
机译：在骨组织再生中，已报道某些聚合物和磷酸钙基复合材料可增强某些生物表面现象，从而促进骨诱导。尽管已显示出无机填料在此类材料形成异位骨中的关键作用，但尚未发表有关聚合物相可能产生的潜在影响的报道。本工作从以下假设开始：聚合物分子量调节流体吸收，这决定了水解速率和生物表面过程的发生。在此，通过将两种不同分子量的l / d，l-丙交酯共聚物与磷酸钙磷灰石挤出来制备两种复合材料。较低分子量的共聚物允许其复合物中较大的流体吸收，这与较高的体外蛋白吸附能力有关。此外，大量的流体吸收导致复合物降解更快，从而产生更粗糙的表面并增强了离子释放。在绵羊肌肉内植入后，只有具有较低分子量聚合物的复合材料才能诱导异位骨形成。除了影响复合材料的生物潜力外，分子量还调节其在循环应力下的粘弹性行为。结果得出结论，设计具有适当理化特性的生物材料对于机械承重部位的骨组织再生至关重要。

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