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首页> 外文期刊>Acta biomaterialia >In vitro hemocompatibility and vascular endothelial cell functionality on titania nanostructures under static and dynamic conditions for improved coronary stenting applications
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In vitro hemocompatibility and vascular endothelial cell functionality on titania nanostructures under static and dynamic conditions for improved coronary stenting applications

机译：二氧化钛纳米结构在静态和动态条件下的体外血液相容性和血管内皮细胞功能，以改善冠状动脉支架应用

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摘要

The usefulness of nanoscale topography in improving vascular response in vitro was established previously on hydrothermally modified titanium surfaces. To propose this strategy of surface modification for translation onto clinically used metallic stents, it is imperative that the surface should be also hemocompatible: an essential attribute for any blood-contacting device. The present in vitro study focuses on a detailed hemocompatibility evaluation of titania nanostructures created through an alkaline hydrothermal route on metallic Ti stent prototypes. Direct interactions of TiO2 nanocues of various morphologies with whole blood were studied under static conditions as well as using an in vitro circulation model mimicking arterial flow, with respect to a polished Ti control. Nanomodified stent surfaces upon contact with human blood showed negligible hemolysis under constant shear and static conditions. Coagulation profile testing indicated that surface roughness of nanomodified stents induced no alterations in the normal clotting times, with insignificant thrombus formation and minimal inflammatory reaction. Endothelialized nanomodified Ti surfaces were found to inhibit both activation as well as aggregation of platelets compared with the control surface, with the endothelium formed on the nanosurfaces having an increased expression of anti-thrombogenic genes. Such a nanotextured Ti surface, which is anti-thrombogenic and promotes endothelialization, would be a cost-effective alternative to drug-eluting stents or polymer-coated stents for overcoming in-stent restenosis.
机译：先前已经在水热改性的钛表面上确立了纳米级形貌在改善体外血管反应中的有用性。为了提出这种表面修饰策略以转化为临床使用的金属支架，必须使表面也具有血液相容性：这是任何血液接触装置的基本属性。目前的体外研究集中在通过钛金属支架原型上的碱性水热途径产生的二氧化钛纳米结构的详细血液相容性评估。研究了各种形态的TiO2纳米粒子与全血的直接相互作用，包括在静态条件下以及使用模拟动脉流动的体外循环模型（相对于抛光的Ti对照）。在恒定的剪切力和静态条件下，与人体血液接触的纳米改性支架表面溶血作用可忽略不计。凝血曲线测试表明，纳米修饰支架的表面粗糙度在正常凝血时间中无变化，血栓形成不明显，炎症反应最小。与对照表面相比，发现内皮化的纳米改性的Ti表面抑制血小板的活化以及聚集，并且在纳米表面上形成的内皮具有增加的抗血栓形成基因的表达。这种纳米结构化的Ti表面具有抗血栓形成作用，可促进内皮化，是克服支架内再狭窄的药物洗脱支架或聚合物涂层支架的经济高效替代品。

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