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首页> 外文期刊>Acta biomaterialia >Graphene and graphene oxide as new nanocarriers for drug delivery applications
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Graphene and graphene oxide as new nanocarriers for drug delivery applications

机译：石墨烯和氧化石墨烯作为新型纳米载体用于药物输送应用

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摘要

The biomedical applications of graphene-based materials, including drug delivery, have grown rapidly in the past few years. Graphene and graphene oxide have been extensively explored as some of the most promising biomaterials for biomedical applications due to their unique properties: two-dimensional planar structure, large surface area, chemical and mechanical stability, superb conductivity and good biocompatibility. These properties result in promising applications for the design of advanced drug delivery systems and delivery of a broad range of therapeutics. In this review we present an overview of recent advances in this field of research. We briefly describe current methods for the surface modification of graphene-based nanocarriers, their biocompatibility and toxicity, followed by a summary of the most appealing examples demonstrated for the delivery of anti-cancer drugs and genes. Additionally, new drug delivery concepts based on controlling mechanisms, including targeting and stimulation with pH, chemical interactions, thermal, photo- and magnetic induction, are discussed. Finally the review is summarized, with a brief conclusion of future prospects and challenges in this field.
机译：在过去的几年中，基于石墨烯的材料的生物医学应用（包括药物输送）得到了迅速发展。石墨烯和氧化石墨烯因其独特的特性而被广泛地探索为生物医学应用中最有希望的生物材料：二维平面结构，大表面积，化学和机械稳定性，极好的电导率以及良好的生物相容性。这些特性为先进的药物输送系统的设计和广泛治疗剂的输送带来了有希望的应用。在这篇综述中，我们概述了该研究领域的最新进展。我们简要介绍了当前基于石墨烯的纳米载体的表面修饰，其生物相容性和毒性的方法，然后总结了展示抗癌药物和基因的最吸引人的例子。此外，还讨论了基于控制机制的新药物输送概念，包括靶向和pH刺激，化学相互作用，热，光和磁感应。最后总结了本综述，并简要总结了该领域的未来前景和挑战。

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