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首页> 外文期刊>Acta Dermato-Venereologica >Epidermal urocanic acid concentration and photoisomerization reactivity in patients with cutaneous malignant melanoma or basal cell carcinoma.
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Epidermal urocanic acid concentration and photoisomerization reactivity in patients with cutaneous malignant melanoma or basal cell carcinoma.

机译:皮肤恶性黑色素瘤或基底细胞癌患者的表皮尿酸浓度和光异构反应性。

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摘要

The relationship of epidermal urocanic acid concentration and photoisomerization reactivity to human skin cancer was studied. Twelve cutaneous malignant melanoma patients, 10 basal cell carcinoma patients and 22 healthy matched controls were enrolled in the study. A solar simulating ultraviolet irradiator was used for phototesting the minimal erythema dose. Using the Finn Chamber technique, urocanic acid was sampled from the healthy skin of the upper back, prior to and after exposure to suberythemal UV doses. The mean values of total and trans-urocanic acid were higher in basal cell carcinoma patients than in controls, but this difference was not statistically significant. No corresponding phenomenon was evident in the case of cutaneous malignant melanoma patients and their controls. Photoisomerization induced by irradiation with 1 mJ/cm2 CIE (Commission Internationale de l'Eclairage) was statistically significantly lower in cutaneous malignant melanoma patients than in controls (p=0.04). A similar trend was seen in basal cell carcinoma patients vs. their controls, but the difference was not significant.
机译:研究了表皮中尿烷酸浓度与光异构化反应性与人皮肤癌的关系。这项研究招募了12名皮肤恶性黑色素瘤患者,10名基底细胞癌患者和22名健康匹配对照。使用模拟太阳的紫外线辐射器对最小红斑剂量进行光测试。使用Finn Chamber技术,在暴露于皮下的紫外线剂量之前和之后,从上背部的健康皮肤中取样尿酸。基底细胞癌患者总和反式尿酸的平均值高于对照组,但这一差异在统计学上不显着。在皮肤恶性黑色素瘤患者及其对照中,没有发现相应的现象。在皮肤恶性黑色素瘤患者中,照射1 mJ / cm2 CIE(国际照明委员会)诱导的光异构化在统计学上显着低于对照组(p = 0.04)。在基底细胞癌患者中,与对照组相比,出现了相似的趋势,但是差异并不显着。

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