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首页> 外文期刊>Acta biomaterialia >Synthesis and characterization of thermoresponsive polyamidoamine-polyethylene glycol-poly(D,L-lactide) core-shell nanoparticles.
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Synthesis and characterization of thermoresponsive polyamidoamine-polyethylene glycol-poly(D,L-lactide) core-shell nanoparticles.

机译：热响应性聚酰胺酰胺-聚乙二醇-聚（D，L-丙交酯）核壳纳米粒子的合成与表征。

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摘要

This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to polyamidoamine (PAMAM) dendrimer G3.0 and subsequent ring-opening polymerization of DLLA. The ninhydrin assay, (1)H NMR, Fourier transform infrared spectroscopy, dynamic light scattering and atomic force microscopy were used to characterize the structure and compositions of dendritic PEG-PDLLA nanoparticles. The sol-gel phase transition of aqueous dendritic PEG-PDLLA solutions was measured using UV-visual spectroscopy. According to our results dendritic PEG-PDLLA nanoparticles in aqueous solution can self-assemble into sub-micron/micron aggregates, the size of which is dependent on temperature and PEG-PDLLA chain length. Further, dendritic PEG-PDLLA solutions exhibit a sol-gel phase transition with increasing temperature. The constructed dendritic PEG-PDLLA nanoparticles possessed high cytocompatibility, which was significantly improved compared with PAMAM dendrimers. The potential of dendritic PEG-PDLLA nanoparticles for encapsulation of water-insoluble drugs such as camptothecin was demonstrated. The dendritic PEG-PDLLA nanoparticles we developed offer greater structural flexibility and provide a novel nanostructured thermoresponsive carrier for drug delivery.
机译：这项工作描述了新型的热响应性高支化聚酰胺基胺-聚乙二醇-聚（D，L-丙交酯）（PAMAM-PEG-PDLLA）核壳纳米粒子的合成和表征。通过将各种链长（1500、6000和12,000 g mol（-1））的PEG与聚酰胺酰胺（PAMAM）树枝状聚合物G3.0缀合，然后进行DLLA的开环聚合反应，合成了一系列树枝状PEG-PDLLA纳米粒子。茚三酮测定，（1）H NMR，傅里叶变换红外光谱，动态光散射和原子力显微镜用于表征树枝状PEG-PDLLA纳米颗粒的结构和组成。使用紫外-可见光谱法测量树状PEG-PDLLA水溶液的溶胶-凝胶相变。根据我们的结果，水溶液中的树状PEG-PDLLA纳米粒子可以自组装成亚微米/微米的聚集体，其大小取决于温度和PEG-PDLLA链长。此外，树枝状PEG-PDLLA溶液随着温度的升高呈现出溶胶-凝胶相变。所构建的树枝状PEG-PDLLA纳米粒子具有高细胞相容性，与PAMAM树枝状大分子相比有显着改善。证明了树突状PEG-PDLLA纳米颗粒用于封装非水溶性药物（如喜树碱）的潜力。我们开发的树突状PEG-PDLLA纳米颗粒具有更大的结构灵活性，并为药物输送提供了新型的纳米结构热响应性载体。

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