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首页> 外文期刊>Acta biomaterialia >Sodium citrate as an effective dispersant for the synthesis of inorganic-organic composites with a nanodispersed mineral phase.
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Sodium citrate as an effective dispersant for the synthesis of inorganic-organic composites with a nanodispersed mineral phase.

机译：柠檬酸钠作为一种有效的分散剂，用于合成具有纳米分散矿物相的无机-有机复合材料。

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Although extensive efforts have been devoted to the development of polymer-ceramic composites for bone repair, those developed thus far were not able to mimic the nanostructure of bone, partly because of the aggregated, microscale organization of the mineral component. As a consequence, homogenization and intermixing of organic and inorganic components remain a major engineering challenge for the development of functional, biomimetic bone-substituting composites. In the current study, various dispersants were evaluated for their potential to be used as biocompatible dispersants in the synthesis of biomimetic composites with a nanodispersed mineral phase. Based on sedimentation experiments, tribasic sodium citrate was selected as the most effective dispersant for the stabilization of calcium phosphate (CaP) suspensions. Specific adsorption of citrate anions onto CaP nanocrystals was shown to result in a strong increase in the negative surface charge of the CaP particles and consequently increased repulsive interparticle forces that were able to overcome attractive van der Waals forces. Using sodium citrate as dispersant at a CaP/citrate ratio of 4.0, CaP-gelatin nanocomposites were fabricated which displayed a nanostructured mineral phase without occurrence of microscale CaP particles. Consequently, aggregation and sedimentation of CaP mineral phase was reduced considerably.
机译：尽管已经为开发用于骨修复的聚合物-陶瓷复合材料进行了广泛的努力，但是迄今为止开发的那些不能模仿骨的纳米结构，部分原因是矿物成分的聚集，微观组织。结果，有机和无机组分的均质化和混合仍然是功能性，仿生骨替代复合材料开发的主要工程挑战。在当前的研究中，评估了各种分散剂在用作具有纳米分散矿物相的仿生复合材料合成中作为生物相容性分散剂的潜力。根据沉淀实验，选择柠檬酸三钠作为稳定磷酸钙（CaP）悬浮液最有效的分散剂。柠檬酸根阴离子在CaP纳米晶体上的特异性吸附已显示出导致CaP颗粒负表面电荷的强烈增加，因此增加了能够克服范德华力的排斥性颗粒间作用力。使用柠檬酸钠作为CaP /柠檬酸盐比率为4.0的分散剂，制备了CaP-明胶纳米复合材料，该复合材料显示出纳米结构的矿物相，而没有出现微型CaP颗粒。因此，CaP矿物相的聚集和沉淀大大减少了。

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