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首页> 外文期刊>Acta biomaterialia >Heparin-immobilized polymers as non-inflammatory and non-thrombogenic coating materials for arsenic trioxide eluting stents.
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Heparin-immobilized polymers as non-inflammatory and non-thrombogenic coating materials for arsenic trioxide eluting stents.

机译：固定有肝素的聚合物，用作三氧化二砷洗脱支架的非炎性和无血栓形成涂层材料。

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摘要

We have synthesized heparin-immobilized copolymers of L-lactide (LA) and 5-methyl-5-benzyloxycarbonate-1,3-dioxan-2-one (MBC) as non-inflammatory and non-thrombogenic biodegradable coating materials. These copolymers were used in fabricating arsenic trioxide (As(2)O(3))-eluting stents to reduce the late-stage adverse events, such as thrombosis, localized hypersensitivity and inflammation, that occur when applying stents to treat coronary artery diseases. Heparinized copolymers effectively reduced platelet adhesion and protein adsorption while increasing the plasma recalcification time and thromboplastin time in vitro. Histological analysis of the polymer-coated stents in a porcine coronary artery injury model indicated that one heparinized copolymer (Hep-Co90, LA:MBC=90:10), with the highest LA content of 90% and the lowest degradation rate, induced the least foreign body reactions and inflammation, which were as small as those induced by bare metal stents. Consequently, Hep-Co90 was used as the stent coating material for local As(2)O(3) delivery. Histomorphometric evaluations suggested no significant difference between bare metal stents and As(2)O(3)-eluting stents at 1 and 3 months post-implantation. At 6 months, the lumen area in the porcine coronary arteries treated with As(2)O(3)-eluting stents is 32.4% higher than those treated with bare metal stents while the neointimal area, neointimal thickness and stenosis rate decreased by 25.8%, 32.5% and 31.2%, respectively. The As(2)O(3)-eluting stent using Hep-Co90 as the drug carrier and stent coating material presented in this study represents a novel promising device in preventing in-stent restenosis.
机译：我们已经合成了肝素固定化的L-丙交酯（LA）和5-甲基-5-苄氧基碳酸1,3-二恶烷-2-酮（MBC），作为非炎症和非血栓性可生物降解的涂料。这些共聚物用于制造三氧化二砷（As（2）O（3））洗脱支架，以减少在应用支架治疗冠状动脉疾病时发生的后期不良事件，例如血栓形成，局部超敏反应和炎症。肝素化共聚物可有效减少血小板粘附和蛋白质吸附，同时增加体外血浆重新钙化时间和凝血活酶时间。猪冠状动脉损伤模型中聚合物涂层支架的组织学分析表明，一种肝素化的共聚物（Hep-Co90，LA：MBC = 90：10），LA含量最高，为90％，降解率最低，可引起肝损伤。最少的异物反应和炎症，与裸金属支架引起的反应和炎症一样小。因此，Hep-Co90用作局部As（2）O（3）输送的支架涂层材料。组织形态计量学评价表明，在植入后1和3个月内，裸金属支架和As（2）O（3）洗脱支架之间无显着差异。在6个月时，用As（2）O（3）洗脱支架治疗的猪冠状动脉腔面积比裸金属支架治疗的高32.4％，而新内膜面积，新内膜厚度和狭窄率降低了25.8％。 ，分别为32.5％和31.2％。在本研究中使用Hep-Co90作为药物载体和支架涂层材料的As（2）O（3）洗脱支架代表了一种新型的有前途的预防支架内再狭窄的装置。

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