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首页> 外文期刊>Acta biomaterialia >Microporous bacterial cellulose as a potential scaffold for bone regeneration.
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Microporous bacterial cellulose as a potential scaffold for bone regeneration.

机译：微孔细菌纤维素作为骨再生的潜在支架。

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摘要

Nanoporous cellulose biosynthesized by bacteria is an attractive biomaterial scaffold for tissue engineering due to its biocompatibility and good mechanical properties. However, for bone applications a microscopic pore structure is needed to facilitate osteoblast ingrowth and formation of a mineralized tissue. Therefore, in this study microporous bacterial cellulose (BC) scaffolds were prepared by incorporating 300-500 microm paraffin wax microspheres into the fermentation process. The paraffin wax microspheres were subsequently removed, and scanning electron microscopy confirmed a microporous surface of the scaffolds while Fourier transform infrared spectroscopy verified the elimination of paraffin and tensile measurements showed a Young's modulus of approximately 1.6 MPa. Microporous BC and nanoporous (control) BC scaffolds were seeded with MC3T3-E1 osteoprogenitor cells, and examined by confocal microscopy and histology for cell distribution and mineral deposition. Cells clustered within the pores of microporous BC, and formed denser mineral deposits than cells grown on control BC surfaces. This work shows that microporous BC is a promising biomaterial for bone tissue engineering applications.
机译：由细菌生物合成的纳米多孔纤维素由于其生物相容性和良好的机械性能而成为用于组织工程的有吸引力的生物材料支架。然而，对于骨应用，需要微观孔结构以促进成骨细胞向内生长和矿化组织的形成。因此，在这项研究中，通过将300-500微米的石蜡微球掺入发酵过程中来制备微孔细菌纤维素（BC）支架。随后除去石蜡蜡微球，并且扫描电子显微镜证实了支架的微孔表面，而傅立叶变换红外光谱证实了石蜡的消除，并且拉伸测量结果显示约1.6MPa的杨氏模量。将微孔BC和纳米孔（对照）BC支架接种MC3T3-E1骨祖细胞，并通过共聚焦显微镜和组织学检查细胞分布和矿物质沉积。细胞在微孔BC的孔内聚集，形成比在对照BC表面生长的细胞更密集的矿物质沉积。这项工作表明，微孔BC是用于骨组织工程应用的有前途的生物材料。

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