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首页> 外文期刊>Acta biomaterialia >Synthesis and characterization of poly(methyl methacrylate)-based experimental bone cements reinforced with TiO2-SrO nanotubes.
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Synthesis and characterization of poly(methyl methacrylate)-based experimental bone cements reinforced with TiO2-SrO nanotubes.

机译：TiO2-SrO纳米管增强的聚（甲基丙烯酸甲酯）基实验骨水泥的合成与表征。

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In an attempt to overcome existing limitations of experimental bone cements we here demonstrate a simple approach to synthesizing strontium-modified titania nanotubes (n-SrO-TiO(2) tubes) and functionalize them using the bifunctional monomer methacrylic acid. Then, using 'grafting from' polymerization with methyl methacrylate, experimental bone cements were produced with excellent mechanical properties, radiopacity and biocompatibility. Transmission electron microscopy (TEM), scanning electron microscopy (SEM), energy-dispersive spectroscopy mapping and backscattered SEM micrographs revealed a uniform distribution of SrO throughout the titanium matrix, with retention of the nanotubular morphology. Nanocomposites were then reinforced with 1, 2, 4 and 6 wt.% of the functionalized metal oxide nanotubes. Under the mixing and dispersion regime employed in this study, 2 wt.% appeared optimal, exhibiting a more uniform dispersion and stronger adhesion of the nanotubes in the poly(methyl methacrylate) matrix, as shown by TEM and SEM. Moreover, this optimum loading provided a significant increase in the fracture toughness (K(IC)) (20%) and flexural strength (40%) in comparison with the control matrix (unfilled) at P<0.05. Examination of the fracture surfaces by SEM showed that toughening was provided by the nanotubes interlocking with the acrylic matrix and crack bridging during fracture. On modifying the n-TiO(2) tubes with strontium oxide the nanocomposites exhibited a similar radiopacity to a commercial bone cement (CMW 1), while exhibiting a significant enhancement of osteoblast cell proliferation (242%) in vitro compared with the control at P<0.05.
机译：为了克服实验骨水泥的现有局限性，我们在这里展示了一种简单的方法来合成锶改性的二氧化钛纳米管（n-SrO-TiO（2）管）并使用双功能单体甲基丙烯酸将其功能化。然后，使用与甲基丙烯酸甲酯的“接枝”聚合反应，生产出具有优异机械性能，射线不透性和生物相容性的实验骨水泥。透射电子显微镜（TEM），扫描电子显微镜（SEM），能量色散谱图和反向散射SEM显微照片显示SrO在整个钛基体中均匀分布，并保留了纳米管形态。然后用1、2、4和6重量％的官能化金属氧化物纳米管增强纳米复合材料。在该研究中采用的混合和分散体系下，2％（重量）似乎是最佳的，如TEM和SEM所示，在聚（甲基丙烯酸甲酯）基体中纳米管表现出更均匀的分散和更强的附着力。此外，与P（0.05）的对照基质（未填充）相比，该最佳载荷使断裂韧性（K（IC））（20％）和抗弯强度（40％）显着增加。通过SEM检查断裂表面表明，由纳米管与丙烯酸基体互锁并且在断裂期间的裂纹桥接提供了增韧。在用氧化锶修饰n-TiO（2）管时，纳米复合材料显示出与商业骨水泥（CMW 1）类似的不透射线性，同时与P对照组相比，在体外具有显着增强的成骨细胞增殖能力（242％）。 <0.05。

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