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首页> 外文期刊>Acta biomaterialia >A novel route in bone tissue engineering: magnetic biomimetic scaffolds.
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A novel route in bone tissue engineering: magnetic biomimetic scaffolds.

机译：骨组织工程学中的一条新途径：仿生磁性支架。

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摘要

In recent years, interest in tissue engineering and its solutions has increased considerably. In particular, scaffolds have become fundamental tools in bone graft substitution and are used in combination with a variety of bio-agents. However, a long-standing problem in the use of these conventional scaffolds lies in the impossibility of re-loading the scaffold with the bio-agents after implantation. This work introduces the magnetic scaffold as a conceptually new solution. The magnetic scaffold is able, via magnetic driving, to attract and take up in vivo growth factors, stem cells or other bio-agents bound to magnetic particles. The authors succeeded in developing a simple and inexpensive technique able to transform standard commercial scaffolds made of hydroxyapatite and collagen in magnetic scaffolds. This innovative process involves dip-coating of the scaffolds in aqueous ferrofluids containing iron oxide nanoparticles coated with various biopolymers. After dip-coating, the nanoparticles are integrated into the structure of the scaffolds, providing the latter with magnetization values as high as 15 emu g(-)(1) at 10 kOe. These values are suitable for generating magnetic gradients, enabling magnetic guiding in the vicinity and inside the scaffold. The magnetic scaffolds do not suffer from any structural damage during the process, maintaining their specific porosity and shape. Moreover, they do not release magnetic particles under a constant flow of simulated body fluids over a period of 8 days. Finally, preliminary studies indicate the ability of the magnetic scaffolds to support adhesion and proliferation of human bone marrow stem cells in vitro. Hence, this new type of scaffold is a valuable candidate for tissue engineering applications, featuring a novel magnetic guiding option.
机译：近年来，对组织工程及其解决方案的兴趣大大增加。特别是，支架已成为骨移植替代的基本工具，并与多种生物制剂结合使用。然而，使用这些常规支架的长期存在的问题在于植入后无法将生物试剂重新装载到支架上。这项工作介绍了磁性支架作为概念上的新解决方案。磁性支架能够通过磁性驱动来吸引和吸收体内生长因子，与磁性颗粒结合的干细胞或其他生物制剂。作者成功地开发了一种简单且廉价的技术，该技术能够将磁性磷灰石中的羟基磷灰石和胶原蛋白制成的标准商品化支架进行转化。该创新方法涉及将支架浸涂在水性铁磁流体中，该水性铁磁流体包含涂覆有各种生物聚合物的氧化铁纳米颗粒。浸涂后，纳米颗粒被整合到支架的结构中，在10 kOe下提供的磁化强度高达15 emu g（-）（1）。这些值适用于生成磁梯度，从而可以在支架附近和内部进行磁导。磁性支架在加工过程中不会受到任何结构破坏，保持其特定的孔隙率和形状。此外，它们在8天的持续模拟体液流量下不会释放磁性颗粒。最后，初步研究表明磁性支架在体外支持人骨髓干细胞粘附和增殖的能力。因此，这种新型支架具有新颖的磁性引导选项，是组织工程应用的有价值的候选者。

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