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首页> 外文期刊>Acta biomaterialia >The chemical form of metallic debris in tissues surrounding metal-on-metal hips with unexplained failure.
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The chemical form of metallic debris in tissues surrounding metal-on-metal hips with unexplained failure.

机译：金属碎片在金属对金属髋关节周围组织中的化学形式，具有无法解释的故障。

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Implant-derived material from metal-on-metal (MOM) hip arthroplasties may be responsible for an unexplained tissue inflammatory response. The chemical form of the metal species in the tissues is predominantly chromium (Cr), but the currently used techniques have not been able to determine whether this is Cr(III) phosphate or Cr(III) oxide. The analytical challenge must overcome the fact that the metal in the tissues is at a relatively low concentration and tissue preparation or the microscopy beam used can affect the results. Microfocus X-ray spectroscopy using a synchrotron beam is useful in addressing both these issues. Using this technique we compared tissue from failed MOM hips with: (1) tissue from metal-on-polyethylene (MOP) hips; (2) chemical standards; (3) metal discs cut from MOM hips. The most abundant implant-related species in all MOM hip tissues contained Cr. Comparison with standards revealed the chemical form was Cr(III) phosphate, which did not vary with manufacturer type (four types analysed) or level of blood metal ions. Cobalt (Co) and molybdenum (Mo) were occasionally present in areas of high Cr. Co was normally found in a metallic state in the tissue, while Mo was found in an oxidized state. The variety of metallic species may have arisen from corrosion, wear or a combination of both. No evidence of Cr(VI) was seen in the tissues examined.
机译：金属对金属（MOM）髋关节置换术的植入物衍生材料可能导致无法解释的组织炎症反应。组织中金属物质的化学形式主要为铬（Cr），但当前使用的技术无法确定这是磷酸Cr（III）还是Cr（III）氧化物。分析上的挑战必须克服以下事实：组织中的金属浓度相对较低，并且组织制备或所用显微镜束可能会影响结果。使用同步加速器束的微焦点X射线光谱学可用于解决这两个问题。使用这种技术，我们将失败的MOM髋关节的组织与以下各项进行了比较：（1）聚乙烯/金属/金属（MOP）髋关节的组织; （2）化学标准; （3）从妈妈臀部切下的金属圆盘。在所有MOM髋关节组织中，与种植体相关的物种最多，其中含有Cr。与标准品的比较表明，化学形式为磷酸Cr（III），其不会随制造商类型（分析的四种类型）或血液中金属离子的含量而变化。高铬地区偶尔存在钴（Co）和钼（Mo）。通常在组织中发现Co为金属状态，而发现Mo为氧化状态。金属种类的多样性可能是由于腐蚀，磨损或两者的结合而产生的。在检查的组织中没有发现Cr（VI）的证据。

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