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首页> 外文期刊>Acta biomaterialia >Plasma-induced polymerization as a tool for surface functionalization of polymer scaffolds for bone tissue engineering: an in vitro study.
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Plasma-induced polymerization as a tool for surface functionalization of polymer scaffolds for bone tissue engineering: an in vitro study.

机译：等离子体诱导的聚合反应作为用于骨组织工程的聚合物支架表面功能化的工具：一项体外研究。

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A commonly applied strategy in the field of tissue engineering (TE) is the use of temporary three-dimensional scaffolds for supporting and guiding tissue formation in various in vitro strategies and in vivo regeneration approaches. The interactions of these scaffolds with highly sensitive bioentities such as living cells and tissues primarily occur through the material surface. Hence, surface chemistry and topological features have principal roles in coordinating biological events at the molecular, cellular and tissue levels on timescales ranging from seconds to weeks. However, tailoring the surface properties of scaffolds with a complex shape and architecture remains a challenge in materials science. Commonly applied wet chemical treatments often involve the use of toxic solvents whose oddments in the construct could be fatal in the subsequent application. Aiming to shorten the culture time in vitro (i.e. prior the implantation of the construct), in this work we propose a modification of previously described bone TE scaffolds made from a blend of starch with polycaprolactone (SPCL). The modification method involves surface grafting of sulfonic or phosphonic groups via plasma-induced polymerization of vinyl sulfonic and vinyl phosphonic acid, respectively. We demonstrate herein that the presence of these anionic functional groups can modulate cell adhesion mediated through the adsorbed proteins (from the culture medium). Under the conditions studied, both vitronectin adsorption and osteoblast proliferation and viability increased in the order SPCL sulfonic-grafted SPCL < phosphonic-grafted SPCL. The results revealed that plasma-induced polymerization is an excellent alternative route, when compared to the commonly used wet chemical treatments, for the surface functionalization of biodevices with complex shape and porosity.
机译：在组织工程（TE）领域中，一种常用的策略是在各种体外策略和体内再生方法中使用临时三维支架来支持和引导组织形成。这些支架与高度敏感的生物实体（例如活细胞和组织）的相互作用主要通过材料表面发生。因此，表面化学和拓扑特征在从几秒到几周的时间尺度上协调分子，细胞和组织水平的生物事件中起主要作用。然而，在材料科学中，定制具有复杂形状和结构的支架的表面性质仍然是一个挑战。常用的湿法化学处理通常涉及使用有毒溶剂，其结构中的杂物在随后的应用中可能是致命的。为了缩短体外培养时间（即在植入构建体之前），在这项工作中，我们提出了对先前描述的由淀粉与聚己内酯（SPCL）的混合物制成的骨TE支架的改进。改性方法包括分别通过等离子体诱导的乙烯基磺酸和乙烯基膦酸的聚合来进行磺酸基或膦酸基团的表面接枝。我们在本文中证明了这些阴离子官能团的存在可以调节通过吸附蛋白（来自培养基）介导的细胞粘附。在研究的条件下，玻连蛋白的吸附以及成骨细胞的增殖和活力均按SPCL 磺酸接枝SPCL <膦酸接枝SPCL的顺序增加。结果表明，与常用的湿法化学处理相比，等离子诱导的聚合是一种具有复杂形状和孔隙率的生物装置的表面功能化的极佳替代方法。

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