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首页> 外文期刊>Acta biomaterialia >A review of the mechanical behavior of CaP and CaP/polymer composites for applications in bone replacement and repair.
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A review of the mechanical behavior of CaP and CaP/polymer composites for applications in bone replacement and repair.

机译：CaP和CaP /聚合物复合材料在骨置换和修复中的机械性能综述。

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Repair of load-bearing defects resulting from disease or trauma remains a critical barrier for bone tissue engineering. Calcium phosphate (CaP) scaffolds are among the most extensively studied for this application. However, CaPs are reportedly too weak for use in such defects and, therefore, have been limited to non-load-bearing applications. This paper reviews the compression, flexural and tensile properties of CaPs and CaP/polymer composites for applications in bone replacement and repair. This review reveals interesting trends that have not, to our knowledge, previously been reported. Data are classified as bulk, scaffolds, and composites, then organized in order of decreasing strength. This allows for general comparisons of magnitudes of strength both within and across classifications. Bulk and scaffold strength and porosity overlap significantly and scaffold data are comparable to bone both in strength and porosity. Further, for compression, all composite data fall below those of the bulk and most of the scaffold. Another interesting trend revealed is that strength decreases with increasing beta-tricalcium phosphate (beta-TCP) content for CaP scaffolds and with increasing CaP content for CaP/polymer composites. The real limitation for CaPs appears not to be strength necessarily, but toughness and reliability, which are rarely characterized. We propose that research should focus on novel ways of toughening CaPs and discuss several potential strategies.
机译：修复由疾病或创伤引起的承重缺陷仍然是骨组织工程设计的关键障碍。磷酸钙（CaP）支架是针对此应用进行最广泛研究的。但是，据报道，CaP太弱而无法用于此类缺陷，因此，CaP仅限于非承重应用。本文综述了CaPs和CaP /聚合物复合材料在骨置换和修复中的压缩，弯曲和拉伸性能。这篇评论揭示了有趣的趋势，据我们所知，以前没有报道过。数据分为散装，脚手架和复合材料，然后按强度递减的顺序进行组织。这样就可以对分类内和分类之间的强度大小进行一般比较。大块和脚手架的强度和孔隙率明显重叠，并且脚手架的强度和孔隙率数据均与骨骼相当。此外，对于压缩，所有复合数据均低于主体和大多数支架的数据。揭示的另一个有趣趋势是，随着CaP支架的β-磷酸三钙（β-TCP）含量增加以及CaP /聚合物复合材料的CaP含量增加，强度降低。 CaPs的真正局限性似乎不是必需的强度，而是韧性和可靠性，而这很少被描述。我们建议研究应集中在加强CaPs的新颖方法上，并讨论几种潜在的策略。

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