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首页> 外文期刊>Acta biomaterialia >A multilayered synthetic human elastin/polycaprolactone hybrid vascular graft with tailored mechanical properties.
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A multilayered synthetic human elastin/polycaprolactone hybrid vascular graft with tailored mechanical properties.

机译：具有定制机械性能的多层合成人弹性蛋白/聚己内酯混合血管移植物。

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摘要

Small-diameter synthetic vascular graft materials fail to match the patency of human tissue conduits used in vascular bypass surgery. The foreign surface retards endothelialization and is highly thrombogenic, while the mismatch in mechanical properties induces intimal hyperplasia. Using recombinant human tropoelastin, we have developed a synthetic vascular conduit for small-diameter applications. We show that tropoelastin enhances endothelial cell attachment (threefold vs. control) and proliferation by 54.7 +/- 1.1% (3 days vs. control). Tropoelastin, when presented as a monomer and when cross-linked into synthetic elastin for biomaterials applications, had low thrombogenicity. Activation of the intrinsic pathway of coagulation, measured by plasma clotting time, was reduced for tropoelastin (60.4 +/- 8.2% vs. control). Platelet attachment was also reduced compared to collagen. Reductions in platelet interactions were mirrored on cross-linked synthetic elastin scaffolds. Tropoelastin was subsequently incorporated into a synthetic elastin/polycaprolactone conduit with mechanical properties optimized to mimic the human internal mammary artery, including permeability, compliance, elastic modulus and burst pressure. Further, this multilayered conduit presented a synthetic elastin internal lamina to circulating blood and demonstrated suturability and mechanical durability in a small scale rabbit carotid interposition model.
机译：小直径的合成血管移植材料无法匹配用于血管搭桥手术的人体组织导管的通畅性。异物表面阻碍内皮化并高度血栓形成，而机械性能不匹配则引起内膜增生。使用重组人原弹性蛋白，我们已经开发出了用于小直径应用的合成血管导管。我们显示原弹性蛋白可增强内皮细胞附着（相对于对照的三倍）和增殖，增幅为54.7 +/- 1.1％（相对于对照，为3天）。 Tropoelastin以单体形式存在，并在生物材料应用中交联到合成弹性蛋白中时，具有较低的血栓形成性。对于原弹性蛋白，通过血浆凝结时间测量的内在凝血途径的活化降低了（与对照相比为60.4 +/- 8.2％）。与胶原蛋白相比，血小板附着也减少了。血小板相互作用的减少反映在交联的合成弹性蛋白支架上。随后将Tropoelastin结合到合成的弹性蛋白/聚己内酯导管中，其机械性能经过优化，可模拟人的乳内动脉，包括通透性，顺应性，弹性模量和爆破压力。此外，该多层导管为循环血液提供了合成的弹性蛋白内部叶片，并在小规模的兔颈动脉介入模型中显示了可缝合性和机械耐久性。

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