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首页> 外文期刊>Acta biomaterialia >Amelogenin-assisted ex vivo remineralization of human enamel: Effects of supersaturation degree and fluoride concentration.
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Amelogenin-assisted ex vivo remineralization of human enamel: Effects of supersaturation degree and fluoride concentration.

机译：Amelogenin辅助的人牙釉质的离体再矿化：过饱和度和氟化物浓度的影响。

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摘要

The formation of organized nanocrystals that resemble enamel is crucial for successful enamel remineralization. Calcium, phosphate and fluoride ions, and amelogenin are important ingredients for the formation of organized hydroxyapatite (HAP) crystals in vitro. However, the effects of these remineralization agents on the enamel crystal morphology have not been thoroughly studied. The objective of this study was to investigate the effects of fluoride ions, supersaturation degree and amelogenin on the crystal morphology and organization of ex vivo remineralized human enamel. Extracted third molars were sliced thin and acid-etched to provide the enamel surface for immersion in different remineralization solutions. The crystal morphology and mineral phase of the remineralized enamel surface were analyzed by field emission-scanning electron microscopy, attenuated total reflection-Fourier transformed infrared and X-ray diffraction. The concentration of fluoride and the supersaturation degree of hydroxyapatite had significant effects on the crystal morphology and crystal organization, which varied from plate-like loose crystals to rod-like densely packed nanocrystal arrays. Densely packed arrays of fluoridated hydroxyapatite nanorods were observed under the following conditions: sigma(HAP)=10.2+/-2.0 with 1.5+/-0.5 mg l(-1) fluoride and 40+/-10 mug ml(-1) amelogenin, pH 6.8+/-0.4. A phase diagram summarizes the conditions that form dense or loose hydroxyapatite nanocrystal structures. This study provides the basis for the development of novel dental materials for caries management.
机译：类似于釉质的有组织的纳米晶体的形成对于成功的釉质再矿化至关重要。钙，磷酸盐和氟离子以及牙釉蛋白是在体外形成有组织羟基磷灰石（HAP）晶体的重要成分。但是，这些再矿化剂对釉质晶体形态的影响尚未得到充分研究。这项研究的目的是研究氟离子，过饱和度和釉质生成素对离体再矿化人釉质的晶体形态和组织的影响。将提取的第三磨牙切成薄片并酸蚀，以提供搪瓷表面，以浸入不同的再矿化溶液中。通过场发射扫描电子显微镜，衰减全反射-傅立叶变换红外和X射线衍射分析了再矿化釉质表面的晶体形态和矿物相。氟化物的浓度和羟基磷灰石的过饱和度对晶体形态和晶体组织有重要影响，从板状的松散晶体到棒状的密集堆积纳米晶体阵列不等。在以下条件下观察到密集排列的氟化羟基磷灰石纳米棒阵列：sigma（HAP）= 10.2 +/- 2.0，含1.5 +/- 0.5 mg l（-1）氟化物和40 +/- 10杯ml（-1）发光素，pH 6.8 +/- 0.4。相图总结了形成致密或疏松的羟基磷灰石纳米晶体结构的条件。这项研究为开发用于龋齿管理的新型牙科材料提供了基础。

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