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首页> 外文期刊>Acta biomaterialia >Novel quantum dots-carboxymethyl chitosan nanocomposite nitric oxide donors capable of detecting release of nitric oxide in situ
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Novel quantum dots-carboxymethyl chitosan nanocomposite nitric oxide donors capable of detecting release of nitric oxide in situ

机译：新型量子点-羧甲基壳聚糖纳米复合一氧化氮供体，能够原位检测一氧化氮的释放

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Nitric oxide (NO) donor compounds are primarily monofunctional in that they release NO under the requisite conditions. To detect the amount and duration of NO released, subsequent analysis methods are required. It would be advantageous if a NO donor compound could both release and detect NO at the same time. This would eliminate potential errors in the analysis. In this paper, novel cadmium telluride quantum dots (CdTe QD)-carboxymethyl chitosan (CMCS) nanocomposite NO donors, including both diazeniumdiolates and fluorescence probes, were fabricated by first synthesizing CdTe QD in CMCS aqueous solution and then reacting NO as well as ethyl bromide with the resultant CdTe QD-CMCS nanocomposites. Transmission electron microscopy, scanning electron microscopy and particle size analysis were used to examine the morphology and size distribution of the CdTe QD-CMCS nanocomposite NO donors. The donors are nanospheres with CdTe QD encapsulated and have dimensions of ～300 nm. Fourier transform infrared spectroscopy, X-ray diffraction, X-ray photoelectron spectroscopy and contact angle tests were employed to characterize the chemical structure of the donors, and the results also show that CdTe QD are well incorporated into CMCS, and many of them are close to the surface of the donors. The precursors of the donors exhibit a fluorescent effect, and the fluorescence can be quenched by NO. The donors can release NO spontaneously in a phosphate-buffered saline solution similar to a physiological environment, and can quantitatively detect the release of NO in situ based on fluorescence quenching of the donors by the NO.
机译：一氧化氮（NO）供体化合物主要是单官能的，因为它们在必要条件下释放NO。为了检测NO的释放量和持续时间，需要后续的分析方法。如果NO供体化合物可以同时释放和检测NO，将是有利的。这样可以消除分析中的潜在错误。本文通过首先在CMCS水溶液中合成CdTe QD，然后使NO与溴化乙锭反应，制备了新颖的碲化镉量子点（CdTe QD）-羧甲基壳聚糖（CMCS）纳米复合NO供体，包括二醇二氮烯二酸酯和荧光探针。与所得的CdTe QD-CMCS纳米复合材料。使用透射电子显微镜，扫描电子显微镜和粒度分析来检查CdTe QD-CMCS纳米复合NO供体的形貌和尺寸分布。供体是包裹有CdTe QD的纳米球，尺寸约为〜300 nm。通过傅里叶变换红外光谱，X射线衍射，X射线光电子能谱和接触角测试来表征施主的化学结构，结果还表明CdTe QD已很好地结合到CMCS中，其中许多是紧密的到捐助者的表面。供体的前体表现出荧光作用，并且荧光可以被NO猝灭。供体可以在类似于生理环境的磷酸盐缓冲盐溶液中自发释放NO，并且可以基于供体的荧光猝灭来定量检测NO的原位释放。

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