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首页> 外文期刊>Acta biomaterialia >Remineralization of artificial dentinal caries lesions by biomimetically modified mineral trioxide aggregate
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Remineralization of artificial dentinal caries lesions by biomimetically modified mineral trioxide aggregate

机译：仿生修饰的三氧化二矿骨料再矿化人工龋齿病变

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Fluoride-releasing restorative materials are available for remineralization of enamel and root caries. However, remineralization of dentin is more difficult than remineralization of enamel due to the paucity of apatite seed crystallites along the lesion surface for heterogeneous crystal growth. Extracellular matrix proteins play critical roles in controlling apatite nucleation/growth in collagenous tissues. This study examined the remineralization efficacy of mineral trioxide aggregate (MTA) in phosphate-containing simulated body fluid (SBF) by incorporating polyacrylic acid and sodium tripolyphosphate as biomimetic analogs of matrix proteins for remineralizing caries-like dentin. Artificial caries-like dentin lesions incubated in SBF were remineralized over a 6 week period using MTA alone or MTA containing biomimetic analogs in the absence or presence of dentin adhesive application. Lesion depths and integrated mineral loss were monitored with microcomputed tomography. The ultrastructure of baseline and remineralized lesions was examined by transmission electron microscopy. Dentin remineralization was best achieved using MTA containing biomimetic analogs regardless of whether an adhesive was applied; dentinal tubules within the remineralized dentin were occluded by apatite. It is concluded that the version of MTA employed in this study may be doped with biomimetic analogs for remineralization of unbonded and bonded artificial caries-like lesions in the presence of SBF.
机译：释放氟化物的修复材料可用于牙釉质和根龋的再矿化。然而，由于沿病灶表面的磷灰石晶种稀疏，无法进行异质晶体生长，因此牙本质的再矿化比牙釉质的再矿化更加困难。细胞外基质蛋白在控制胶原组织中的磷灰石成核/生长中起关键作用。这项研究通过掺入聚丙烯酸和三聚磷酸钠作为基质蛋白的仿生类似物来再矿化龋齿样牙本质，研究了三氧化二矿聚集体（MTA）在含磷酸盐的模拟体液（SBF）中的再矿化功效。在不存在或不存在牙本质粘合剂的情况下，仅使用MTA或含有MTA的仿生类似物在6周的时间内使矿物质在SBF中的人工龋齿样牙本质矿化。病变深度和综合矿物质流失用微型计算机断层扫描监测。通过透射电子显微镜检查基线和再矿化病变的超微结构。无论是否使用粘合剂，使用含有MTA的仿生类似物都能最好地实现牙本质再矿化。磷灰石阻塞了再矿化牙本质中的牙本质小管。结论是，本研究中使用的MTA版本可以掺有仿生类似物，以在存在SBF的情况下使未结合和结合的人造龋齿样病灶再矿化。

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