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首页> 外文期刊>Acta biomaterialia >A novel approach for blood purification: Mixed-matrix membranes combining diffusion and adsorption in one step
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A novel approach for blood purification: Mixed-matrix membranes combining diffusion and adsorption in one step

机译：一种新颖的血液净化方法：一步将扩散和吸附结合在一起的混合基质膜

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摘要

Hemodialysis is a commonly used blood purification technique in patients requiring kidney replacement therapy. Sorbents could increase uremic retention solute removal efficiency but, because of poor biocompatibility, their use is often limited to the treatment of patients with acute poisoning. This paper proposes a novel membrane concept for combining diffusion and adsorption of uremic retention solutes in one step: the so-called mixed-matrix membrane (MMM). In this concept, adsorptive particles are incorporated in a macro-porous membrane layer whereas an extra particle-free membrane layer is introduced on the blood-contacting side of the membrane to improve hemocompatibility and prevent particle release. These dual-layer mixed-matrix membranes have high clean-water permeance and high creatinine adsorption from creatinine model solutions. In human plasma, the removal of creatinine and of the protein-bound solute para-aminohippuric acid (PAH) by single and dual-layer membranes is in agreement with the removal achieved by the activated carbon particles alone, showing that under these experimental conditions the accessibility of the particles in the MMM is excellent. This study proves that the combination of diffusion and adsorption in a single step is possible and paves the way for the development of more efficient blood purification devices, excellently combining the advantages of both techniques.
机译：血液透析是需要肾脏替代疗法的患者常用的血液净化技术。吸附剂可以提高尿毒症保留溶质的去除效率，但是由于生物相容性差，其使用通常仅限于治疗急性中毒患者。本文提出了一种新颖的膜概念，将尿毒症保留溶质的扩散和吸附结合在一个步骤中：所谓的混合基质膜（MMM）。在这个概念中，吸附性颗粒被掺入大孔膜层中，而多余的无颗粒膜层被引入到膜的血液接触侧，以改善血液相容性并防止颗粒释放。这些双层混合基质膜具有较高的净水渗透率和从肌酐模型溶液中获得的较高肌酐吸附率。在人血浆中，通过单层和双层膜去除肌酐和结合蛋白质的溶质对氨基马尿酸（PAH）与仅通过活性炭颗粒实现的去除是一致的，这表明在这些实验条件下， MMM中粒子的可访问性非常好。这项研究证明了将扩散和吸附结合在一个步骤中是可能的，并且为将更高效的血液净化设备开发与卓越地结合了这两种技术的优势铺平了道路。

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