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首页> 外文期刊>Acta biomaterialia >Biological response on a titanium implant-grade surface functionalized with modular peptides
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Biological response on a titanium implant-grade surface functionalized with modular peptides

机译：模块化肽功能化的钛植入物级表面的生物响应

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Titanium (Ti) and its alloys are among the most successful implantable materials for dental and orthopedic applications. The combination of excellent mechanical and corrosion resistance properties makes them highly desirable as endosseous implants that can withstand a demanding biomechanical environment. Yet, the success of the implant depends on its osteointegration, which is modulated by the biological reactions occurring at the interface of the implant. A recent development for improving biological responses on the Ti-implant surface has been the realization that bifunctional peptides can impart material binding specificity not only because of their molecular recognition of the inorganic material surface, but also through their self-Assembly and ease of biological conjugation properties. To assess peptide-based functionalization on bioactivity, the present authors generated a set of peptides for implant-grade Ti, using cell surface display methods. Out of 60 unique peptides selected by this method, two of the strongest titanium binding peptides, TiBP1 and TiBP2, were further characterized for molecular structure and adsorption properties. These two peptides demonstrated unique, but similar molecular conformations different from that of a weak binder peptide, TiBP60. Adsorption measurements on a Ti surface revealed that their disassociation constants were 15-fold less than TiBP60. Their flexible and modular use in biological surface functionalization were demonstrated by conjugating them with an integrin recognizing peptide motif, RGDS. The functionalization of the Ti surface by the selected peptides significantly enhanced the bioactivity of osteoblast and fibroblast cells on implant-grade materials. ? 2012 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
机译：钛（Ti）及其合金是最成功的牙科和整形外科植入材料之一。优异的机械和耐腐蚀性能相结合，使它们成为可以承受苛刻生物力学环境的骨内植入物。然而，植入物的成功取决于其骨整合，这是由植入物界面处发生的生物反应调节的。改善Ti植入物表面生物反应的最新进展是认识到，双功能肽不仅由于其对无机材料表面的分子识别，而且还通过其自组装和易于生物结合而赋予材料结合特异性。属性。为了评估基于肽的生物活性功能，作者使用细胞表面展示方法生成了一组用于植入级Ti的肽。通过这种方法选择的60种独特肽中，进一步鉴定了两个最强的钛结合肽TiBP1和TiBP2的分子结构和吸附特性。这两种肽表现出独特的但相似的分子构象，与弱结合剂肽TiBP60不同。在Ti表面的吸附测量表明，它们的解离常数比TiBP60小15倍。通过将它们与整合素识别肽基序RGDS结合，证明了它们在生物表面功能化中的灵活和模块化用途。所选肽对Ti表面的功能化显着增强了植入级材料上成骨细胞和成纤维细胞的生物活性。 ？ 2012年Acta Materialia Inc.由Elsevier Ltd.发行。保留所有权利。

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