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首页> 外文期刊>Acta biomaterialia >Bone regeneration in rat calvarial defects implanted with fibrous scaffolds composed of a mixture of silicate and borate bioactive glasses
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Bone regeneration in rat calvarial defects implanted with fibrous scaffolds composed of a mixture of silicate and borate bioactive glasses

机译：植入由硅酸盐和硼酸盐生物活性玻璃组成的纤维支架的大鼠颅骨缺损的骨再生

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Previous studies have evaluated the capacity of porous scaffolds composed of a single bioactive glass to regenerate bone. In the present study, scaffolds composed of a mixture of two different bioactive glasses (silicate 13-93 and borate 13-93B3) were created and evaluated for their response to osteogenic MLO-A5 cells in vitro and their capacity to regenerate bone in rat calvarial defects in vivo. The scaffolds, which have similar microstructures (porosity = 58-67%) and contain 0, 25, 50 and 100 wt.% 13-93B3 glass, were fabricated by thermally bonding randomly oriented short fibers. The silicate 13-93 scaffolds showed a better capacity to support cell proliferation and alkaline phosphatase activity than the scaffolds containing borate 13-93B3 fibers. The amount of new bone formed in the defects implanted with the 13-93 scaffolds at 12 weeks was 31%, compared to values of 25, 17 and 20%, respectively, for the scaffolds containing 25, 50 and 100% 13-93B3 glass. The amount of new bone formed in the 13-93 scaffolds was significantly higher than in the scaffolds containing 50 and 100% 13-93B3 glass. While the 13-93 fibers were only partially converted to hydroxyapatite at 12 weeks, the 13-93B3 fibers were fully converted and formed a tubular morphology. Scaffolds composed of an optimized mixture of silicate and borate bioactive glasses could provide the requisite architecture to guide bone regeneration combined with a controllable degradation rate that could be beneficial for bone and tissue healing.
机译：以前的研究已经评估了由单一生物活性玻璃组成的多孔支架再生骨骼的能力。在本研究中，创建了由两种不同生物活性玻璃（硅酸盐13-93和硼酸盐13-93B3）的混合物组成的支架，并评估了它们对体外成骨性MLO-A5细胞的反应以及它们在大鼠颅骨中再生骨骼的能力。体内缺陷。通过热粘合随机取向的短纤维来制造具有相似的微结构（孔隙率＝ 58-67％）并包含0、25、50和100重量％的13-93B3玻璃的支架。硅酸盐13-93支架比包含硼酸盐13-93B3纤维的支架表现出更好的支持细胞增殖和碱性磷酸酶活性的能力。在第12周植入13-93支架的缺损中形成的新骨量为31％，而对于含有25％，50％和100％的13-93B3玻璃的支架，其新骨量分别为25％，17％和20％。 。在13-93支架中形成的新骨量明显高于在含有50％和100％13-93B3玻璃的支架中形成的新骨量。虽然13-93纤维在12周时仅部分转化为羟基磷灰石，但13-93B3纤维却被完全转化并形成了管状形态。由硅酸盐和硼酸盐生物活性玻璃的优化混合物组成的支架可以提供必要的架构来指导骨骼再生，并结合可控的降解速率，从而有利于骨骼和组织的愈合。

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