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首页> 外文期刊>Acta biomaterialia >Effects of crosslinking on the mechanical properties, drug release and cytocompatibility of protein polymers
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Effects of crosslinking on the mechanical properties, drug release and cytocompatibility of protein polymers

机译：交联对蛋白质聚合物的机械性能，药物释放和细胞相容性的影响

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摘要

Recombinant elastin-like protein polymers are increasingly being investigated as component materials of a variety of implantable medical devices. This is chiefly a result of their favorable biological properties and the ability to tailor their physical and mechanical properties. In this report, we explore the potential of modulating the water content, mechanical properties, and drug release profiles of protein films through the selection of different crosslinking schemes and processing strategies. We find that the selection of crosslinking scheme and processing strategy has a significant influence on all aspects of protein polymer films. Significantly, utilization of a confined, fixed volume, as well as vapor-phase crosslinking strategies, decreased protein polymer equilibrium water content. Specifically, as compared to uncrosslinked protein gels, water content was reduced for genipin (15.5%), glutaraldehyde (GTA, 24.5%), GTA vapor crosslinking (31.6%), disulfide (SS, 18.2%) and SS vapor crosslinking (25.5%) (P < 0.05). Distinct crosslinking strategies modulated protein polymer stiffness, strain at failure and ultimate tensile strength (UTS). In all cases, vapor-phase crosslinking produced the stiffest films with the highest UTS. Moreover, both confined, fixed volume and vapor-phase approaches influenced drug delivery rates, resulting in decreased initial drug burst and release rates as compared to solution phase crosslinking. Tailored crosslinking strategies provide an important option for modulating the physical, mechanical and drug delivery properties of protein polymers.
机译：重组弹性蛋白样蛋白质聚合物作为各种可植入医疗设备的组成材料正在被越来越多地研究。这主要是由于它们良好的生物学特性以及调整其物理和机械特性的能力的结果。在本报告中，我们探讨了通过选择不同的交联方案和加工策略来调节蛋白质膜的水含量，机械性能和药物释放曲线的潜力。我们发现，交联方案和加工策略的选择对蛋白质聚合物薄膜的各个方面都有重要影响。重要的是，利用固定的固定体积以及气相交联策略降低了蛋白质聚合物平衡水含量。具体而言，与未交联的蛋白质凝胶相比，Genipin（15.5％），戊二醛（GTA，24.5％），GTA蒸气交联（31.6％），二硫键（SS，18.2％）和SS蒸气交联（25.5％）的水含量降低。 ）（P <0.05）。不同的交联策略可调节蛋白质聚合物的刚度，断裂应变和极限拉伸强度（UTS）。在所有情况下，气相交联都能产生具有最高UTS的最硬膜。而且，密闭，固定体积和气相方法都影响药物传递速率，与溶液相交联相比，导致初始药物爆发和释放速率降低。量身定制的交联策略为调节蛋白质聚合物的物理，机械和药物传递特性提供了重要的选择。

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