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首页> 外文期刊>Acta biomaterialia >Quantification of the interaction between biomaterial surfaces and bacteria by 3-D modeling
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Quantification of the interaction between biomaterial surfaces and bacteria by 3-D modeling

机译：通过3-D建模量化生物材料表面与细菌之间的相互作用

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摘要

It is general knowledge that bacteria/surface interactions depend on the surface topography. However, this well-known dependence has so far not been included in the modeling efforts. We propose a model for calculating interaction energies between spherical bacteria and arbitrarily structured 3-D surfaces, combining the Derjaguin, Landau, Verwey, Overbeek theory and an extended surface element integration method. The influence of roughness on the interaction (for otherwise constant parameters, e.g. surface chemistry, bacterial hydrophobicity) is quantified, demonstrating that common experimental approaches which consider amplitude parameters of the surface topography but which ignore spacing parameters fail to adequately describe the influence of surface roughness on bacterial adhesion. The statistical roughness profile parameters arithmetic average height (representing an amplitude parameter) and peak density (representing a spacing parameter) both exert a distinct influence on the interaction energy. The influence of peak density on the interaction energy increases with decreasing arithmetic average height and contributes significantly to the total interaction energy with an arithmetic average height below 70 nm. With the aid of the proposed model, different sensitivity ranges of the interaction between rough surfaces and bacteria are identified. On the nanoscale, the spacing parameter of the surface dominates the interaction, whereas on the microscale the amplitude parameter adopts the governing role.
机译：细菌/表面相互作用取决于表面形貌是常识。但是，到目前为止，尚未将这种众所周知的依赖性包括在建模工作中。我们结合Derjaguin，Landau，Verwey，Overbeek理论和扩展的表面元素整合方法，提出了一个用于计算球形细菌与任意结构的3D表面之间的相互作用能的模型。量化了粗糙度对相互作用的影响（对于不变的参数，例如表面化学，细菌疏水性），这表明考虑表面形貌的振幅参数但忽略间距参数的常见实验方法无法充分描述表面粗糙度的影响对细菌的粘附。统计粗糙度轮廓参数的算术平均高度（代表振幅参数）和峰密度（代表间距参数）都对相互作用能产生明显的影响。峰值密度对相互作用能的影响随着算术平均高度的降低而增加，并且对算术平均高度低于70 nm的总相互作用能有显着贡献。借助提出的模型，可以确定粗糙表面与细菌之间相互作用的不同灵敏度范围。在纳米尺度上，表面的间距参数主导相互作用，而在微观尺度上，振幅参数起主导作用。

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