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首页> 外文期刊>Acta biomaterialia >Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin.
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Structure, chemical composition and mechanical properties of human and rat cementum and its interface with root dentin.

机译：人和大鼠牙骨质的结构，化学组成和力学性能及其与牙本质的界面。

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This work seeks to establish comparisons of the physical properties of rat and human cementum, root dentin and their interface, including the cementum-dentin junction (CDJ), as a basis for future studies of the entire periodontal complex using rats as animal models. In this study the structure, site-specific chemical composition and mechanical properties of cementum and its interface with root dentin taken from 9- to 12-month-old rats were compared to the physiologically equivalent 40- to 55-year-old human age group using qualitative and quantitative characterization techniques, including histology, atomic force microscopy (AFM), micro-X-ray computed tomography, Raman microspectroscopy and AFM-based nanoindentation. Based on results from this study, cementum taken from the apical third of the respective species can be represented as a woven fabric with radially and circumferentially oriented collagen fibers. In both species the attachment of cementum to root dentin is defined by a stiffness-graded interface (CDJ/cementum-dentin interface). However, it was concluded that cementum and the cementum-dentin interface from a 9- to 12-month-old rat could be more mineralized, resulting in noticeably decreased collagen fiber hydration and significantly higher modulus values under wet conditions for cementum and CDJ (E(rat-cementum)=12.7+/-2.6 GPa; E(rat-CDJ)=11.6+/-3.2 GPa) compared to a 40- to 55-year-old human (E(human-cementum)=3.73+/-1.8 GPa; E(human-CDJ)=1.5+/-0.7 GPa). The resulting data illustrated that the extensions of observations made from animal models to humans should be justified with substantial and equivalent comparison of data across age ranges (life spans) of mammalian species.
机译：这项工作旨在建立对大鼠和人类牙骨质，牙本质牙本质及其界面（包括牙骨质-牙本质连接（CDJ））的物理特性的比较，以作为将来以大鼠为动物模型研究整个牙周复合体的基础。在这项研究中，将牙骨质的结构，特定部位的化学成分和力学性能及其与9到12个月大的大鼠牙根牙本质的界面与生理等效的40到55岁的人类年龄组进行了比较。使用定性和定量表征技术，包括组织学，原子力显微镜（AFM），X射线计算机断层扫描，拉曼光谱和基于AFM的纳米压痕。根据这项研究的结果，取自各个物种的顶端三分之一的牙骨质可表示为具有径向和周向定向胶原纤维的机织织物。在这两个物种中，牙骨质与根部牙本质的附着都由刚度渐变的界面（CDJ /水泥-牙本质界面）定义。然而，得出的结论是，从9个月到12个月大的大鼠，牙骨质和牙骨质-牙本质界面可能更矿化，从而导致在湿润条件下牙骨质和CDJ的胶原纤维水合显着降低，模量值明显更高（E （大鼠-水泥）= 12.7 +/- 2.6 GPa; E（大鼠-CDJ）= 11.6 +/- 3.2 GPa）与40至55岁的人相比（E（人类-水泥）= 3.73 + / -1.8 GPa; E（人类CDJ）= 1.5 +/- 0.7 GPa）。所得数据表明，应通过对哺乳动物物种的不同年龄范围（寿命）的数据进行实质性和等效的比较，证明从动物模型向人类进行的观察扩展是合理的。

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