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首页> 外文期刊>Acta biomaterialia >The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repair.
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The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repair.

机译：L-乳酸低聚物表面接枝的聚（丙交酯-共-乙交酯）和羟基磷灰石的纳米复合支架。

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Nanohydroxyapatite (op-HA) surface-modified with l-lactic acid oligomer (LAc oligomer) was prepared by LAc oligomer grafted onto the hydroxyapatite (HA) surface. The nanocomposite of op-HA/PLGA with different op-HA contents of 5, 10, 20 and 40wt.% in the composite was fabricated into three-dimensional scaffolds by the melt-molding and particulate leaching methods. PLGA and the nanocomposite of HA/PLGA with 10wt.% of ungrafted hydroxyapatite were used as the controls. The scaffolds were highly porous with evenly distributed and interconnected pore structures, and the porosity wasaround 90%. Besides the macropores of 100-300microm created by the leaching of NaCl particles, the micropores (1-50microm) in the pore walls increased with increasing content of op-HA in the composites of op-HA/PLGA. The op-HA particles could disperse more uniformly than those of pure HA in PLGA matrix. The 20wt.% op-HA/PLGA sample exhibited the maximum mechanical strength, including bending strength (4.14MPa) and compressive strength (2.31MPa). The cell viability and the areas of the attached osteoblasts on the films of 10wt.% op-HA/PLGA and 20wt.% op-HA/PLGA were evidently higher than those on the other composites. For the animal test, there was rapid healing in the defects treated with 10 and 20wt.% op-HA/PLGA, where bridging by a large bony callus was observed at 24weeks post-surgery. There was non-union of radius defects implanted with PLGA and in the untreated group. This was verified by the Masson's trichrome staining photomicrographs of histological analysis. All the data extrapolated that the composite with 10 and 20wt.% op-HA exhibited better comprehensive properties and were the optimal composites for bone repairing.
机译：通过将LAc低聚物接枝到羟基磷灰石（HA）表面上，制备了用1-乳酸低聚物（LAc低聚物）表面改性的纳米羟基磷灰石（op-HA）。通过熔融成型和颗粒浸出法将复合物中op-HA含量分别为5、10、20和40wt。％的op-HA / PLGA纳米复合材料制成三维支架。将PLGA和具有10wt。％的未接枝羟基磷灰石的HA / PLGA的纳米复合材料用作对照。支架是高度多孔的，具有均匀分布和相互连接的孔结构，孔隙率约为90％。除了NaCl颗粒浸出产生的100-300微米大孔外，孔壁中的微孔（1-50微米）随着op-HA / PLGA复合材料中op-HA含量的增加而增加。 op-HA粒子比纯HA粒子在PLGA基质中的分散更为均匀。重量百分比为20％的op-HA / PLGA样品表现出最大的机械强度，包括弯曲强度（4.14MPa）和抗压强度（2.31MPa）。 10wt。％op-HA / PLGA和20 wt。％op-HA / PLGA的薄膜的细胞活力和附着成骨细胞的面积明显高于其他复合材料。对于动物试验，用10％和20％重量的op-HA / PLGA治疗的缺损有快速的愈合，在手术后24周观察到大骨b的桥接。在未治疗组中，植入PLGA的radius骨缺损不愈合。通过组织学分析的Masson三色染色显微照片证实了这一点。所有数据推断，具有10％和20wt。％op-HA的复合材料表现出更好的综合性能，并且是用于骨修复的最佳复合材料。

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